ZFIN ID: ZDB-PUB-190530-7
A dual functional turn-on non-toxic chemosensor for highly selective and sensitive visual detection of Mg2+ and Zn2+: the solvent-controlled recognition effect and bio-imaging application
Wang, Y., Wang, Z.G., Song, X.Q., Chen, Q., Tian, H., Xie, C.Z., Li, Q.Z., Xu, J.Y.
Date: 2019
Source: The Analyst   144(13): 4024-4032 (Journal)
Registered Authors: Wang, Yang
Keywords: none
MeSH Terms:
  • Animals
  • Density Functional Theory
  • Drinking Water/analysis
  • Fluorescence
  • Fluorescent Dyes/chemical synthesis
  • Fluorescent Dyes/chemistry*
  • Fluorescent Dyes/toxicity
  • Humans
  • Hydrazones/chemical synthesis
  • Hydrazones/chemistry*
  • Hydrazones/toxicity
  • Isoquinolines/chemical synthesis
  • Isoquinolines/chemistry*
  • Isoquinolines/toxicity
  • Lakes/analysis
  • Limit of Detection
  • MCF-7 Cells
  • Magnesium/analysis*
  • Models, Chemical
  • Solvents/chemistry
  • Spectrometry, Fluorescence/methods
  • Zebrafish
  • Zinc/analysis*
PubMed: 31140476 Full text @ Analyst
A new dual functional turn-on chemosensor, 2,6-diformyl-4-methylphenol-di(isoquinolinyl-1-hydrazone) (HL), has been developed, which could highly selectively discriminate Mg2+ and Zn2+ in different solvent systems. The chemosensor HL exhibits rapid visual turn-on fluorescence enhancing recognition toward Mg2+/Zn2+, which is not interfered by other cations, especially for respective congeners Ca2+/Cd2+. The remarkable fluorescence enhancement (71-fold or 11-fold) was observed after adding Mg2+ in acetonitrile or Zn2+ in DMF-H2O solvent systems. Additionally such a solvent medium-controlled platform could achieve the quantitative determination of Mg2+ and Zn2+ quantitation with low detection limits of 2.97 × 10-8 M and 3.07 × 10-7 M, respectively. Furthermore, the turn-on fluorescence sensing mechanism is also investigated by 1H NMR, FT-IR and ESI-MS spectroscopy. Density functional theory (DFT) calculations derive optimized geometries of HL and its complexes. Notably, non-toxic HL also can be successfully applied as a visual probe for the practical determination of Mg2+/Zn2+ in MCF-7 cells, Zebrafish larvae, syrup and water samples, which might provide extensive application in biology and medicine fields.