PUBLICATION
A dual functional turn-on non-toxic chemosensor for highly selective and sensitive visual detection of Mg2+ and Zn2+: the solvent-controlled recognition effect and bio-imaging application
- Authors
- Wang, Y., Wang, Z.G., Song, X.Q., Chen, Q., Tian, H., Xie, C.Z., Li, Q.Z., Xu, J.Y.
- ID
- ZDB-PUB-190530-7
- Date
- 2019
- Source
- The Analyst 144(13): 4024-4032 (Journal)
- Registered Authors
- Wang, Yang
- Keywords
- none
- MeSH Terms
-
- Animals
- Density Functional Theory
- Drinking Water/analysis
- Fluorescence
- Fluorescent Dyes/chemical synthesis
- Fluorescent Dyes/chemistry*
- Fluorescent Dyes/toxicity
- Humans
- Hydrazones/chemical synthesis
- Hydrazones/chemistry*
- Hydrazones/toxicity
- Isoquinolines/chemical synthesis
- Isoquinolines/chemistry*
- Isoquinolines/toxicity
- Lakes/analysis
- Limit of Detection
- MCF-7 Cells
- Magnesium/analysis*
- Models, Chemical
- Solvents/chemistry
- Spectrometry, Fluorescence/methods
- Zebrafish
- Zinc/analysis*
- PubMed
- 31140476 Full text @ Analyst
Citation
Wang, Y., Wang, Z.G., Song, X.Q., Chen, Q., Tian, H., Xie, C.Z., Li, Q.Z., Xu, J.Y. (2019) A dual functional turn-on non-toxic chemosensor for highly selective and sensitive visual detection of Mg2+ and Zn2+: the solvent-controlled recognition effect and bio-imaging application. The Analyst. 144(13):4024-4032.
Abstract
A new dual functional turn-on chemosensor, 2,6-diformyl-4-methylphenol-di(isoquinolinyl-1-hydrazone) (HL), has been developed, which could highly selectively discriminate Mg2+ and Zn2+ in different solvent systems. The chemosensor HL exhibits rapid visual turn-on fluorescence enhancing recognition toward Mg2+/Zn2+, which is not interfered by other cations, especially for respective congeners Ca2+/Cd2+. The remarkable fluorescence enhancement (71-fold or 11-fold) was observed after adding Mg2+ in acetonitrile or Zn2+ in DMF-H2O solvent systems. Additionally such a solvent medium-controlled platform could achieve the quantitative determination of Mg2+ and Zn2+ quantitation with low detection limits of 2.97 × 10-8 M and 3.07 × 10-7 M, respectively. Furthermore, the turn-on fluorescence sensing mechanism is also investigated by 1H NMR, FT-IR and ESI-MS spectroscopy. Density functional theory (DFT) calculations derive optimized geometries of HL and its complexes. Notably, non-toxic HL also can be successfully applied as a visual probe for the practical determination of Mg2+/Zn2+ in MCF-7 cells, Zebrafish larvae, syrup and water samples, which might provide extensive application in biology and medicine fields.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping