PUBLICATION
Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
- Authors
- Krasnow, A.M., Ford, M.C., Valdivia, L.E., Wilson, S.W., Attwell, D.
- ID
- ZDB-PUB-190510-18
- Date
- 2018
- Source
- Nature Neuroscience 21: 24-28 (Other)
- Registered Authors
- Krasnow, Anna, Valdivia, Leonardo, Wilson, Steve
- Keywords
- none
- MeSH Terms
-
- Zebrafish
- Animals
- SOXE Transcription Factors/genetics
- SOXE Transcription Factors/metabolism
- Mivacurium/pharmacology
- Neurons/drug effects
- Neurons/physiology*
- Myelin Sheath/physiology*
- Myelin Basic Protein/genetics
- Myelin Basic Protein/metabolism
- Chelating Agents/pharmacology
- Spinal Cord/cytology
- Action Potentials/drug effects
- Action Potentials/genetics
- Axons/drug effects
- Axons/physiology*
- Luminescent Proteins/genetics
- Luminescent Proteins/metabolism
- Tetrodotoxin/pharmacology
- Animals, Genetically Modified
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- Neuromuscular Nondepolarizing Agents/pharmacology
- Calcium/metabolism*
- Calcium/pharmacology
- Clustered Regularly Interspaced Short Palindromic Repeats
- Oligodendroglia/physiology*
- Egtazic Acid/analogs & derivatives
- Egtazic Acid/pharmacology
- Sodium Channel Blockers/pharmacology
- PubMed
- 29230052 Full text @ Nat. Neurosci.
Citation
Krasnow, A.M., Ford, M.C., Valdivia, L.E., Wilson, S.W., Attwell, D. (2018) Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo. Nature Neuroscience. 21:24-28.
Abstract
How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+]i in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high frequency of [Ca2+]i transients and prevented by [Ca2+]i buffering. Sheath elongation occurs ~1 h after [Ca2+]i elevation. Sheath shortening is associated with a low frequency of [Ca2+]i transients but with longer duration [Ca2+]i bursts. Thus, [Ca2+]i controls myelin sheath development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping