PUBLICATION
Rice Bran Ash Mineral Extract Increases Pigmentation through the p-ERK Pathway in Zebrafish (Danio rerio)
- Authors
- Kim, Y.M., Lee, E.C., Lim, H.M., Seo, Y.K.
- ID
- ZDB-PUB-190507-32
- Date
- 2019
- Source
- International Journal of Molecular Sciences 20(9): (Journal)
- Registered Authors
- Keywords
- melanogenesis, p-ERK signaling pathway, pigmentation, zebrafish
- MeSH Terms
-
- Animals
- MAP Kinase Signaling System/drug effects
- Melanins/metabolism
- Microphthalmia-Associated Transcription Factor/genetics
- Microphthalmia-Associated Transcription Factor/metabolism
- Oryza/chemistry*
- Phosphorylation/drug effects
- Pigmentation/drug effects*
- Plant Extracts/chemistry*
- Plant Extracts/pharmacology*
- Up-Regulation/drug effects
- Zebrafish/genetics
- Zebrafish/physiology*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 31052497 Full text @ Int. J. Mol. Sci.
Citation
Kim, Y.M., Lee, E.C., Lim, H.M., Seo, Y.K. (2019) Rice Bran Ash Mineral Extract Increases Pigmentation through the p-ERK Pathway in Zebrafish (Danio rerio). International Journal of Molecular Sciences. 20(9):.
Abstract
The purpose of the present study is to evaluate the effect of rice bran ash mineral extract (RBM) on pigmentation in zebrafish (Danio rerio). Melanin has the ability to block ultraviolet (UV) radiation and scavenge free oxygen radicals, thus protecting the skin from their harmful effects. Agents that increase melanin synthesis in melanocytes may reduce the risk of photodamage and skin cancer. The present study investigates the effect of RBM on pigmentation in zebrafish and the underlying mechanism. RBM was found to significantly increase the expression of microphthalmia-associated transcription factor (MITF), a key transcription factor involved in melanin production. RBM also suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), which negatively regulates zebrafish pigmentation. Together, these results suggest that RBM promotes melanin biosynthesis in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping