PUBLICATION
The effects of fluorene-9-bisphenol on female zebrafish (Danio rerio) reproductive and exploratory behaviors
- Authors
- Mi, P., Zhang, Q.P., Zhang, S.H., Wang, C., Zhang, S.Z., Fang, Y.C., Gao, J.Z., Feng, D.F., Chen, D.Y., Feng, X.Z.
- ID
- ZDB-PUB-190507-18
- Date
- 2019
- Source
- Chemosphere 228: 398-411 (Journal)
- Registered Authors
- Keywords
- Anxiety/depression-like behavior, Courtship behavior, Exploratory behavior, Fluorene-9-bisphenol, Zebrafish
- MeSH Terms
-
- Animals
- Benzhydryl Compounds/adverse effects*
- Benzhydryl Compounds/chemistry
- Exploratory Behavior/drug effects*
- Female
- Fluorenes/chemistry*
- Phenols/adverse effects*
- Phenols/chemistry
- Reproduction/drug effects*
- Zebrafish
- PubMed
- 31048237 Full text @ Chemosphere
- CTD
- 31048237
Citation
Mi, P., Zhang, Q.P., Zhang, S.H., Wang, C., Zhang, S.Z., Fang, Y.C., Gao, J.Z., Feng, D.F., Chen, D.Y., Feng, X.Z. (2019) The effects of fluorene-9-bisphenol on female zebrafish (Danio rerio) reproductive and exploratory behaviors. Chemosphere. 228:398-411.
Abstract
Endocrine disruptor chemicals induce adverse effects to animals' development, reproduction and behavior in environment. We investigated the effects of fluorene-9-bisphenol (BHPF), one substitute of bisphenol A, on courtship behavior and exploratory behavior of adult zebrafish. Customized apparatus was used to evaluate courtship behavior. The result showed that the male spent less time with BHPF and anti-oestrogenic fulvestrant (FULV) treated female in region of approaching (ROA). Courtship index between BHPF-exposed female and male decreased. The body orientation of BHPF- and FULV-exposed female to male decreased. Furthermore, BHPF exposure downregulated the expression of genes related to estrogen receptor, steroidogenesis and upregulated oxidative stress related genes. It indicated that BHPF exposure interfered the preference of male and female in courtship, and induced detrimental effects on reproduction. BHPF treatment decreased locomotor activity and time spent in top, increased freezing bouts, and induced anxiety/depression-like behavior. The tyrosine hydroxylase in brain decreased under BHPF exposure. Here we showed the potential adverse effects of BHPF on reproduction and exploratory behaviors.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping