PUBLICATION
Modeling gut-brain interactions in zebrafish
- Authors
- de Abreu, M.S., Giacomini, A.C.V.V., Sysoev, M., Demin, K.A., Alekseeva, P.A., Spagnoli, S.T., Kalueff, A.V.
- ID
- ZDB-PUB-190321-4
- Date
- 2019
- Source
- Brain research bulletin 148: 55-62 (Review)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- CNS, behavior, gut microbiota, immunology, the endocrine system
- MeSH Terms
-
- Animals
- Behavior, Animal/physiology
- Brain/microbiology
- Brain/physiology*
- Central Nervous System Diseases/microbiology
- Central Nervous System Diseases/physiopathology
- Disease Models, Animal
- Endocrine System/metabolism
- Gastrointestinal Microbiome/physiology*
- Humans
- Models, Animal
- Neurosciences
- Zebrafish/metabolism
- Zebrafish/microbiology*
- PubMed
- 30890360 Full text @ Brain Res. Bull.
Citation
de Abreu, M.S., Giacomini, A.C.V.V., Sysoev, M., Demin, K.A., Alekseeva, P.A., Spagnoli, S.T., Kalueff, A.V. (2019) Modeling gut-brain interactions in zebrafish. Brain research bulletin. 148:55-62.
Abstract
Mounting clinical and experimental evidence suggests the gut-brain interplay as a novel important paradigm in translational neuroscience, including the critical role for gut microbiota in modulating brain development and behavior, as well as neuroimmune and neuroendocrine responses. Animal models are an indispensable tool in studying CNS disorders and their mechanisms. Recently, the zebrafish (Danio rerio) has become a powerful new model organism in neuroscience, including studying the gut-brain axis. Here, we discuss zebrafish models of gut-brain interplay, endocrine and toxicological effects of zebrafish microbiota, and their impact on immune and behavioral processes. We particularly emphasize the growing utility of zebrafish models in gut-brain research, as they foster future discoveries of new interconnections between these systems.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping