PUBLICATION
Glycine Regulates Neural Stem Cell Proliferation During Development via Lnx1-Dependent Notch Signaling
- Authors
- Bekri, A., Liao, M., Drapeau, P.
- ID
- ZDB-PUB-190306-5
- Date
- 2019
- Source
- Frontiers in molecular neuroscience 12: 44 (Journal)
- Registered Authors
- Drapeau, Pierre
- Keywords
- LNX1, NSCs, Notch activity, glycine signaling, neurogenesis
- MeSH Terms
- none
- PubMed
- 30833887 Full text @ Front. Mol. Neurosci.
Citation
Bekri, A., Liao, M., Drapeau, P. (2019) Glycine Regulates Neural Stem Cell Proliferation During Development via Lnx1-Dependent Notch Signaling. Frontiers in molecular neuroscience. 12:44.
Abstract
During development of the zebrafish embryo, glycine signaling promotes the differentiation of neural stem cells (NSCs). We found that glycine signaling suppresses the expression of Ligand of Numb X1 (lnx1, Ligand of numb protein-x1), a gene of unknown function during NSC differentiation that is selectively expressed in the embryonic central nervous system (CNS). As a consequence, Numb levels were stabilized and Notch activity (measured as her4.1 expression) was reduced, promoting NSC differentiation. These consequent actions were blocked by knockdown of lnx1. In contrast, lnx1 overexpression increased NSC proliferation and led to defects of neural tube closure at the early stages of development. Thus, our data provide evidence that glycine/lnx1 signaling modulates NSC proliferation by regulation of Notch signaling.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping