PUBLICATION
Protective Effects of Plathymenia reticulata and Connarus favosus Aqueous Extracts against Cadmium- and Mercury-Induced Toxicities
- Authors
- Gombeau, K., de Oliveira, R.B., Sarrazin, S.L.F., Mourão, R.H.V., Bourdineaud, J.P.
- ID
- ZDB-PUB-190216-7
- Date
- 2019
- Source
- Toxicological research 35: 25-35 (Journal)
- Registered Authors
- Keywords
- Cadmium, Danio rerio, Methylmercury, Oxidative stress, Plant extract, Saccharomyces cerevisiae
- MeSH Terms
- none
- PubMed
- 30766655 Full text @ Toxicol Res
Citation
Gombeau, K., de Oliveira, R.B., Sarrazin, S.L.F., Mourão, R.H.V., Bourdineaud, J.P. (2019) Protective Effects of Plathymenia reticulata and Connarus favosus Aqueous Extracts against Cadmium- and Mercury-Induced Toxicities. Toxicological research. 35:25-35.
Abstract
The extracts of Plathymenia reticulata and Connarus favosus are widely used in the folk medicine. The potential protective effects of these extracts have been evaluated against cadmium in the yeast Saccharomyces cerevisiae, and against mercurial contamination in zebrafish Danio rerio. In yeast, both extracts efficiently protected the Δycf1 mutant strain exposed to cadmium chloride restoring the growth, the expression of stress-response genes and decreasing the level of oxidative stress. In zebrafish, the supplementation of methylmercury-contaminated diet with both plant extracts similarly protected fish through the suppression of the methylmercury-induced lipid peroxidation, decrease of acetylcholinesterase activity, and restoring the expression levels of stress-response genes. This study particularly demonstrates the protective potential of both aqueous extracts against methylmercury, and could represent an interesting alternative for the Amazonian fish-eating communities to cope with the impact of chronic exposure to contaminated diets.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping