PUBLICATION
Effects of PCB-77 in adult zebrafish after exposure during early life stages
- Authors
- Quintaneiro, C., Soares, A.M.V.M., Costa, D., Monteiro, M.S.
- ID
- ZDB-PUB-190209-10
- Date
- 2019
- Source
- Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 54(5): 478-483 (Journal)
- Registered Authors
- Soares, Amadeu
- Keywords
- , endocrine disruption, fish, ovaries, persistent organic pollutants, vitellogenin
- MeSH Terms
-
- Animals
- Endocrine Disruptors/toxicity*
- Estrogens/metabolism
- Female
- Male
- Ovary/drug effects*
- Ovary/growth & development
- Ovary/metabolism
- Polychlorinated Biphenyls/toxicity*
- Reproduction/drug effects
- Vitellogenins/metabolism
- Water Pollutants, Chemical/toxicity*
- Zebrafish/growth & development
- Zebrafish/metabolism*
- PubMed
- 30732533 Full text @ J. Environ. Sci. Health A Tox. Hazard. Subst. Environ. Eng.
Citation
Quintaneiro, C., Soares, A.M.V.M., Costa, D., Monteiro, M.S. (2019) Effects of PCB-77 in adult zebrafish after exposure during early life stages. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. 54(5):478-483.
Abstract
Polychlorinated biphenyls (PCBs) are a class of industrial chemicals that cause endocrine changes, since they are able to bind to estrogen receptors and interfere with estrogen-regulated processes, such as fish vitellogenesis. Therefore, the present work aimed to assess potential endocrine effects of PCB-77 exposure during zebrafish (Danio rerio) gonadal differentiation. To achieve that, zebrafish juveniles were exposed to increasing concentrations of PCB-77 for 14 days during a critical window of gonad differentiation (30-44 days post-fertilization). Vitellogenin (Vtg) levels and several endpoints such as survival, growth, gonadosomatic index (GSI) and hepatosomatic index were recorded at the end of exposure and/or after 3 months in clean medium. The results obtained showed a reduction of Vtg-like proteins in juveniles, just after exposure to PCB-77 accompanied, after 3 months, by a decrease in gonadal Vtg levels and GSI of females. These results suggest that exposure to PCB-77 during the critical window of gonadal differentiation decreased vitellogenesis in juvenile zebrafish which lasted until adulthood affecting the normal development of female gonad, which might have further implications in reproduction success.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping