PUBLICATION
Toxicity of Aqueous L-Selenomethionine Exposure to Early Life-Stages of the Fathead Minnow (Pimephales promelas)
- Authors
- Gerhart, A.K., Hecker, M., Janz, D.M.
- ID
- ZDB-PUB-190121-5
- Date
- 2019
- Source
- Bulletin of environmental contamination and toxicology 102(3): 323-328 (Journal)
- Registered Authors
- Janz, David M.
- Keywords
- Aqueous, Deformities, Embryo, Fish, Selenium, Selenomethionine
- MeSH Terms
-
- Animals
- Cyprinidae/anatomy & histology
- Cyprinidae/growth & development
- Cyprinidae/physiology*
- Embryo, Nonmammalian/anatomy & histology
- Embryo, Nonmammalian/drug effects
- Embryonic Development/drug effects
- Selenomethionine/toxicity*
- Swimming
- Toxicity Tests
- Water Pollutants, Chemical
- PubMed
- 30661092 Full text @ Bull. Environ. Contam. Toxicol.
Citation
Gerhart, A.K., Hecker, M., Janz, D.M. (2019) Toxicity of Aqueous L-Selenomethionine Exposure to Early Life-Stages of the Fathead Minnow (Pimephales promelas). Bulletin of environmental contamination and toxicology. 102(3):323-328.
Abstract
Aqueous exposures to selenomethionine (SeMet), the major form of selenium (Se) in the diet, represent a rapid and simplified method for determining the embryotoxic effects of SeMet. Using fathead minnows (Pimephales promelas) as a model test organism, the objective of this study was to evaluate the effects of waterborne exposure to elevated SeMet on embryos from fertilization to swim-up. Newly fertilized embryos were exposed for 6 days to 30, 90, 270, 810, 2430, 7290, 21,870, and 65,610 µg Se/L (as SeMet). Survival, hatchability, days to hatch, and the frequency and severity of deformities (total and type) were quantified. SeMet exposure reduced hatchability and days to hatch at concentrations ≥ 21870 µg/L. Significant decreases in survival and significant increases in the incidence and severity of deformities were observed at concentrations ≥ 810 µg/L. The results suggest that early life-stage fathead minnows are more tolerant to aqueous exposure to SeMet compared to medaka and zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping