PUBLICATION
Avocado Oil Extract Modulates Auditory Hair Cell Function through the Regulation of Amino Acid Biosynthesis Genes
- Authors
- Nam, Y.H., Rodriguez, I., Jeong, S.Y., Pham, T.N.M., Nuankaew, W., Kim, Y.H., Castañeda, R., Jeong, S.Y., Park, M.S., Lee, K.W., Lee, J.S., Kim, D.H., Park, Y.H., Kim, S.H., Moon, I.S., Choung, S.Y., Hong, B.N., Jeong, K.W., Kang, T.H.
- ID
- ZDB-PUB-190113-3
- Date
- 2019
- Source
- Nutrients 11(1): (Journal)
- Registered Authors
- Keywords
- HEI-OC1, avocado oil, hair cell, mice, sensorineural hearing loss, zebrafish
- MeSH Terms
-
- Amino Acids/biosynthesis*
- Animals
- Auditory Perception/drug effects
- Cochlea/cytology
- Cochlea/drug effects
- Cochlea/metabolism
- Gene Expression Regulation/drug effects*
- Hair Cells, Auditory/drug effects*
- Hair Cells, Auditory/metabolism
- Hair Cells, Auditory/physiology
- Hearing Loss, Noise-Induced/drug therapy
- Hearing Loss, Noise-Induced/genetics
- Hearing Loss, Noise-Induced/metabolism
- Hearing Loss, Noise-Induced/physiopathology
- Hearing Loss, Sensorineural*/drug therapy
- Hearing Loss, Sensorineural*/genetics
- Hearing Loss, Sensorineural*/metabolism
- Hearing Loss, Sensorineural*/physiopathology
- Metabolic Networks and Pathways/drug effects
- Metabolic Networks and Pathways/genetics
- Mice
- Persea/chemistry*
- Phytotherapy*
- Plant Extracts/pharmacology
- Plant Extracts/therapeutic use
- Plant Oils/pharmacology*
- Plant Oils/therapeutic use
- Sequence Analysis, RNA
- Zebrafish
- PubMed
- 30626089 Full text @ Nutrients
- CTD
- 30626089
Citation
Nam, Y.H., Rodriguez, I., Jeong, S.Y., Pham, T.N.M., Nuankaew, W., Kim, Y.H., Castañeda, R., Jeong, S.Y., Park, M.S., Lee, K.W., Lee, J.S., Kim, D.H., Park, Y.H., Kim, S.H., Moon, I.S., Choung, S.Y., Hong, B.N., Jeong, K.W., Kang, T.H. (2019) Avocado Oil Extract Modulates Auditory Hair Cell Function through the Regulation of Amino Acid Biosynthesis Genes. Nutrients. 11(1).
Abstract
Sensorineural hearing loss (SNHL) is one of the most common causes of disability, affecting over 466 million people worldwide. However, prevention or therapy of SNHL has not been widely studied. Avocado oil has shown many health benefits but it has not yet been studied in regards to SNHL. Therefore, we aimed to investigate the efficacy of avocado oil on SNHL in vitro and in vivo and elucidate its mode of action. For the present study, we used enhanced functional avocado oil extract (DKB122). DKB122 led to recovery of otic hair cells in zebrafish after neomycin-induced otic cell damage. Also, DKB122 improved auditory sensory transmission function in a mouse model of noise induced-hearing loss and protected sensory hair cells in the cochlea. In addition, RNA sequencing was performed to elucidate the mechanism involved. KEGG pathway enrichment analysis of differentially expressed genes showed that DKB122 protected House Ear Institute-Organ of Corti 1 (HEI-OC1) cells against neomycin-related alterations in gene expression due to oxidative stress, cytokine production and protein synthesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping