ZFIN ID: ZDB-PUB-190113-18
Expression of RNA-binding protein Rbfox1l demarcates a restricted population of dorsal telencephalic neurons within the adult zebrafish brain
Ma, F., Dong, Z., Berberoglu, M.A.
Date: 2019
Source: Gene expression patterns : GEP   31: 32-41 (Journal)
Registered Authors: Berberoglu, Michael, Dong, Zhiqiang
Keywords: Adult zebrafish brain, Dc region, Dm region, Dorsal telencephalon, Rbfox RNA-binding proteins, Rbfox2
MeSH Terms:
  • Animals
  • Purkinje Cells/metabolism*
  • RNA-Binding Proteins/genetics*
  • RNA-Binding Proteins/metabolism
  • Telencephalon/cytology
  • Telencephalon/metabolism*
  • Zebrafish
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/metabolism
PubMed: 30634066 Full text @ Gene Expr. Patterns
Rbfox RNA-binding proteins are expressed in the adult mammalian brain and are required for proper brain development and function. Studies in mice and humans have implicated Rbfox1/RBFOX1 in autism, neuronal excitation and epilepsy, and Rbfox2/RBFOX2 in cerebellar development. The zebrafish has emerged as a prominent model system for brain study, possessing neuroanatomical conservation with mammals and an extensive capacity for adult neurogenesis and plasticity. In this study, we characterize Rbfox1l and Rbfox2 expression in the adult zebrafish brain. While Rbfox2 is expressed broadly, Rbfox1l is expressed in restricted populations of neurons in the dorsal telencephalon and cerebellum. In the dorsal telencephalon, Rbfox1l is expressed in a specific population of neurons spanning Dm and Dc regions. In the cerebellum, Rbfox1l and Rbfox2 are expressed in the Purkinje cell layer, reminiscent of Rbfox1 and Rbfox2 expression in the mammalian cerebellum. Our findings motivate future studies of Rbfox function in the zebrafish brain.