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ZFIN ID: ZDB-PUB-181224-14
Immune responses in cardiac repair and regeneration: a comparative point of view
Lai, S.L., Marín-Juez, R., Stainier, D.Y.R.
Date: 2018
Source: Cellular and molecular life sciences : CMLS   76(7): 1365-1380 (Review)
Registered Authors: Lai, Shih-Lei (Ben), Marín-Juez, Rubén, Stainier, Didier
Keywords: Comparative analysis, Macrophages, Medaka, Myocardial infarction, Neonatal mice, Neutrophils, Salamander, Scar formation, Scar resolution, Zebrafish
MeSH Terms:
  • Animals
  • HMGB1 Protein/metabolism
  • Heart/physiology*
  • Macrophages/immunology
  • Macrophages/metabolism
  • Models, Animal
  • Myocardial Infarction/metabolism
  • Myocardial Infarction/pathology
  • Neutrophils/immunology
  • Neutrophils/metabolism
  • Reactive Oxygen Species/metabolism
  • Regeneration*
PubMed: 30578442 Full text @ Cell. Mol. Life Sci.
Immediately after cardiac injury, the immune system plays major roles in repair and regeneration as it becomes involved in a number of processes including damage-associated signaling, inflammation, revascularization, cardiomyocyte dedifferentiation and replenishment, and fibrotic scar formation/resolution. Recent studies have revealed that different immune responses occur in the various experimental models capable or incapable of cardiac regeneration, and that harnessing these immune responses might improve cardiac repair. In light of this concept, this review analyzes current knowledge about the immune responses to cardiac injury from a comparative perspective. Insights gained from such comparative analyses may provide ways to modulate the immune response as a potential therapeutic strategy for cardiac disease.