PUBLICATION

Scutoids are a geometrical solution to three-dimensional packing of epithelia

Authors
Gómez-Gálvez, P., Vicente-Munuera, P., Tagua, A., Forja, C., Castro, A.M., Letrán, M., Valencia-Expósito, A., Grima, C., Bermúdez-Gallardo, M., Serrano-Pérez-Higueras, Ó., Cavodeassi, F., Sotillos, S., Martín-Bermudo, M.D., Márquez, A., Buceta, J., Escudero, L.M.
ID
ZDB-PUB-181218-8
Date
2018
Source
Nature communications   9: 2960 (Journal)
Registered Authors
Cavodeassi, Florencia
Keywords
none
MeSH Terms
  • Animals
  • Biophysical Phenomena
  • Cell Shape*
  • Computational Biology
  • Drosophila
  • Epithelial Cells/cytology*
  • Epithelium/embryology*
  • Epithelium/physiology*
  • Female
  • Models, Biological*
  • Morphogenesis
  • Salivary Glands/cytology
  • Zebrafish
PubMed
30054479 Full text @ Nat. Commun.
Abstract
As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of mathematical modelling that cells in bent epithelia can undergo intercalations along the apico-basal axis. This phenomenon forces cells to have different neighbours in their basal and apical surfaces. As a consequence, epithelial cells adopt a novel shape that we term "scutoid". The detailed analysis of diverse tissues confirms that generation of apico-basal intercalations between cells is a common feature during morphogenesis. Using biophysical arguments, we propose that scutoids make possible the minimization of the tissue energy and stabilize three-dimensional packing. Hence, we conclude that scutoids are one of nature's solutions to achieve epithelial bending. Our findings pave the way to understand the three-dimensional organization of epithelial organs.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Errata and Notes