PUBLICATION
Chemical Screening Using a Zebrafish Model for Liver Progenitor Cell-Driven Liver Regeneration
- Authors
- Ko, S., Shin, D.
- ID
- ZDB-PUB-181212-24
- Date
- 2019
- Source
- Methods in molecular biology (Clifton, N.J.) 1905: 83-90 (Other)
- Registered Authors
- Ko, Sungjin, Shin, Donghun
- Keywords
- Biliary epithelial cells, Chemical screen, Hepatocyte ablation, Liver progenitor cells, Nitroreductase
- MeSH Terms
-
- Animals
- Cell Dedifferentiation
- Cell Proliferation
- Liver Regeneration/drug effects*
- Zebrafish
- Ablation Techniques
- Small Molecule Libraries/pharmacology*
- Disease Models, Animal
- Stem Cells/cytology*
- Stem Cells/metabolism
- Cell Differentiation
- Hepatocytes/cytology*
- Hepatocytes/metabolism
- PubMed
- 30536092 Full text @ Meth. Mol. Biol.
Citation
Ko, S., Shin, D. (2019) Chemical Screening Using a Zebrafish Model for Liver Progenitor Cell-Driven Liver Regeneration. Methods in molecular biology (Clifton, N.J.). 1905:83-90.
Abstract
Following massive hepatocyte ablation in zebrafish, biliary epithelial cells can extensively give rise to hepatocytes through liver progenitor cells (LPCs). The zebrafish liver injury model is an important system to elucidate the molecular mechanisms underlying LPC-driven liver regeneration. Here, we describe a chemical screening method using the zebrafish model for identifying small molecules that can modulate LPC-driven liver regeneration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping