PUBLICATION
Whole-Brain Neuronal Activity Displays Crackling Noise Dynamics
- Authors
- Ponce-Alvarez, A., Jouary, A., Privat, M., Deco, G., Sumbre, G.
- ID
- ZDB-PUB-181127-3
- Date
- 2018
- Source
- Neuron 100(6): 1446-1459.e6 (Journal)
- Registered Authors
- Sumbre, Germán
- Keywords
- GcaMP, calcium imaging, gap junctions, light-sheet microscopy, motor behavior, phase transitions, scale invariance, sensory modulation, whole-brain dynamics, zebrafish
- MeSH Terms
-
- Animals
- Brain/cytology*
- Gap Junctions/physiology
- Larva
- Models, Neurological*
- Neural Pathways/physiology
- Neurons/physiology*
- Noise*
- Nonlinear Dynamics*
- Probability
- Zebrafish
- PubMed
- 30449656 Full text @ Neuron
Citation
Ponce-Alvarez, A., Jouary, A., Privat, M., Deco, G., Sumbre, G. (2018) Whole-Brain Neuronal Activity Displays Crackling Noise Dynamics. Neuron. 100(6):1446-1459.e6.
Abstract
Previous studies suggest that the brain operates at a critical point in which phases of order and disorder coexist, producing emergent patterned dynamics at all scales and optimizing several brain functions. Here, we combined light-sheet microscopy with GCaMP zebrafish larvae to study whole-brain dynamics in vivo at near single-cell resolution. We show that spontaneous activity propagates in the brain's three-dimensional space, generating scale-invariant neuronal avalanches with time courses and recurrence times that exhibit statistical self-similarity at different magnitude, temporal, and frequency scales. This suggests that the nervous system operates close to a non-equilibrium phase transition, where a large repertoire of spatial, temporal, and interactive modes can be supported. Finally, we show that gap junctions contribute to the maintenance of criticality and that, during interactions with the environment (sensory inputs and self-generated behaviors), the system is transiently displaced to a more ordered regime, conceivably to limit the potential sensory representations and motor outcomes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping