PUBLICATION
Photo-Powered Artificial Organelles for ATP Generation and Life-Sustainment
- Authors
- Zheng, D.W., Xu, L., Li, C.X., Dong, X., Pan, P., Zhang, Q.L., Li, B., Zeng, X., Zhang, X.Z.
- ID
- ZDB-PUB-181101-5
- Date
- 2018
- Source
- Advanced materials (Deerfield Beach, Fla.) 30(52): e1805038 (Journal)
- Registered Authors
- Keywords
- ATP generation, artificial organelles, cell engineering, nano-materials, photocatalysis
- MeSH Terms
-
- Adenosine Triphosphate*/chemistry
- Adenosine Triphosphate*/metabolism
- Animals
- Animals, Genetically Modified
- Artificial Cells*/chemistry
- Artificial Cells*/radiation effects
- COS Cells
- Chlorocebus aethiops
- Disease Models, Animal
- Fasting/metabolism
- Glucose/deficiency
- Intracellular Space/metabolism
- Light
- Mice
- Myocardial Infarction/metabolism
- Myocardial Infarction/therapy*
- Myocardium/metabolism
- Photochemical Processes
- Phototherapy*
- Rats, Sprague-Dawley
- Zebrafish
- PubMed
- 30378187 Full text @ Adv. Mater. Weinheim
Citation
Zheng, D.W., Xu, L., Li, C.X., Dong, X., Pan, P., Zhang, Q.L., Li, B., Zeng, X., Zhang, X.Z. (2018) Photo-Powered Artificial Organelles for ATP Generation and Life-Sustainment. Advanced materials (Deerfield Beach, Fla.). 30(52):e1805038.
Abstract
Adenosine triphosphate (ATP) is the most important immediate energy source for driving intracellular biochemical reactions in nearly all life forms. Controllable generation of ATP in life is still an unrealized goal. Here, thylakoid fragments are recombined with lipid molecules to synthesize a synthetic/biological hybrid proteoliposome, named highly efficient life-support intracellular opto-driven system (HELIOS) for the generation of ATP. With red light irradiation, HELIOS can improve the intracellular ATP concentration to 1.38-2.45 times in various cell lines. Moreover, it is noticed that HELIOS-mediated ATP generation can comprehensively promote cell functions such as protein synthesis and insulin secretion. At organ and individual levels, it is also proved that HELIOS can rescue a mouse heart from myocardial infarction and sustain life of fasting zebrafish Danio rerio models. The photo-powered artificial organelle can deepen our understanding of metabolism and enable the development of optical therapy that targets intracellular energy supply.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping