ZFIN ID: ZDB-PUB-180929-5
Sweet Fish. Fish Models for the Study of Hyperglycemia and Diabetes
Krishnan, J., Rohner, N.
Date: 2018
Source: Journal of diabetes   11(3): 193-203 (Review)
Registered Authors: Krishnan, Jaya, Rohner, Nicolas
Keywords: Cavefish, Diabetes mellitus, Trout, Zebrafish
MeSH Terms:
  • Animals
  • Characiformes/physiology*
  • Diabetes Mellitus/physiopathology*
  • Disease Models, Animal*
  • Hyperglycemia/etiology
  • Hyperglycemia/physiopathology*
  • Oncorhynchus mykiss/physiology*
  • Zebrafish/physiology*
PubMed: 30264455 Full text @ J Diabetes
Fish are good for your health - in more ways than you might expect. For one, eating fish is a common dietary recommendation for a healthy diet. But fish have much more to provide than omega-3 fatty acids to your circulatory system. Some fish species now serve as important and innovative model systems for diabetes research providing novel and unique advantages compared to classical research models. Not surprisingly, the largest share of diabetes research in fish occurs in the laboratory workhorse amongst the fishes, the so-called zebrafish (Danio rerio). Established as a genetic model system to study development, these small cyprinid fish have eventually conquered almost every scientific discipline, and over the last decade emerged as an important model system for metabolic diseases, including diabetes mellitus. In this review, we highlight the practicability of zebrafish to study diabetes and hyperglycemia, and summarize some of the recent research and breakthroughs using this model. Equally exciting, however, is the appearance of another emerging discipline, one that is taking advantage of evolution by studying cases of naturally occurring insulin resistance in fish species. We will briefly discuss two such models in this review, the rainbow trout (Oncorhynchus mykiss) and the cavefish (Astyanax mexicanus).