PUBLICATION
Acute fluoxetine differently affects aggressive display in zebrafish phenotypes
- Authors
- Barbosa, H.P., Lima-Maximino, M.G., Maximino, C.
- ID
- ZDB-PUB-180927-16
- Date
- 2018
- Source
- Aggressive behavior 45(1): 62-69 (Journal)
- Registered Authors
- Maximino, Caio
- Keywords
- aggressive display, fluoxetine, phenotypic differences, serotonin, zebrafish
- MeSH Terms
-
- Aggression/drug effects*
- Animals
- Behavior, Animal/drug effects*
- Fluoxetine/pharmacology*
- Phenotype
- Selective Serotonin Reuptake Inhibitors/pharmacology*
- Species Specificity
- Zebrafish
- PubMed
- 30255506 Full text @ Aggress Behav
Citation
Barbosa, H.P., Lima-Maximino, M.G., Maximino, C. (2018) Acute fluoxetine differently affects aggressive display in zebrafish phenotypes. Aggressive behavior. 45(1):62-69.
Abstract
Zebrafish have been introduced as a model organism in behavioral neuroscience and biological psychiatry, increasing the breadth of findings using fish to study the neurobiology of aggression. Phenotypic differences between leopard and longfin zebrafish were exploited in order to elucidate the role of phasic serotonin in aggressive displays on this species. The present study, revealed differences in aggressive display between leopard and longfin zebrafish, and a discrepant effect of acute fluoxetine in both populations. In mirror-induced aggression, leopard animals showed higher display latencies than longfin, as well as lower display duration and frequency (Experiment 1). Moreover, 2.5 mg/kg fluoxetine decreased the duration and frequency of display in longfin, but not leopard; and 5 mg/kg fluoxetine increased display frequency in leopard, but not longfin (Experiment 2). It is suggested that zebrafish from the longfin phenotype show more aggressive motivation and readiness in the mirror-induced aggression test than leopard, and that acute fluoxetine increases aggression in leopard and decreased it in longfin zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping