PUBLICATION
A Life in Vision
- Authors
- Dowling, J.E.
- ID
- ZDB-PUB-180918-7
- Date
- 2018
- Source
- Annual review of vision science 4: 1-23 (Review)
- Registered Authors
- Dowling, John E.
- Keywords
- autobiography, dark adaptation, dopamine, inherited retinal degenerations, retinal circuitry, vitamin A, zebrafish
- MeSH Terms
-
- History, 21st Century
- History, 20th Century
- Vision, Ocular*
- Humans
- Ophthalmology/history*
- Biomedical Research/history
- PubMed
- 30222531 Full text @ Annu Rev Vis Sci
Citation
Dowling, J.E. (2018) A Life in Vision. Annual review of vision science. 4:1-23.
Abstract
I was drawn into research in George Wald's laboratory at Harvard, where as an undergraduate and graduate student, I studied vitamin A deficiency and dark adaptation. A chance observation while an assistant professor at Harvard led to the major research of my career-to understand the functional organization of vertebrate retinas. I started with a retinal circuit analysis of the primate retina with Brian Boycott and intracellular retinal cell recordings in mudpuppies with Frank Werblin. Subsequent pharmacology studies with Berndt Ehinger primarily with fish focused on dopamine and neuromodulation. Using zebrafish, we studied retinal development, neuronal connectivity, and the effects of genetic mutations on retinal structure and function. Now semi-retired, I have returned to primate retinal circuitry, undertaking a connectomic analysis of the human fovea in Jeffrey Lichtman's laboratory.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping