PUBLICATION
Environmentally relevant concentrations of the flame retardant tris(1,3-dichloro-2-propyl) phosphate change morphology of female zebrafish
- Authors
- Zhu, Y., Lin, D., Yang, D., Jia, Y., Liu, C.
- ID
- ZDB-PUB-180827-3
- Date
- 2018
- Source
- Chemosphere 212: 358-364 (Journal)
- Registered Authors
- Zhu, Ya
- Keywords
- Flame retardant, Gene expression, Landmark-based geometric morphometrics, TDCIPP, Zebrafish
- MeSH Terms
-
- Animals
- Dose-Response Relationship, Drug
- Environment*
- Female
- Flame Retardants/toxicity*
- Organophosphorus Compounds/toxicity*
- Water Pollutants, Chemical/toxicity*
- Zebrafish/anatomy & histology*
- PubMed
- 30145427 Full text @ Chemosphere
- CTD
- 30145427
Citation
Zhu, Y., Lin, D., Yang, D., Jia, Y., Liu, C. (2018) Environmentally relevant concentrations of the flame retardant tris(1,3-dichloro-2-propyl) phosphate change morphology of female zebrafish. Chemosphere. 212:358-364.
Abstract
Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) was considered as a re-emerging environmental pollutant, and accumulated evidences suggested that it was global distributed in various environmental media. However, effect of TDCIPP on fish morphology remained largely unknown. In this study, one-month old zebrafish (Danio rerio) were exposed to 0, 0.05, 0.5 or 5 μg/L TDCIPP for 120 days, and effects on fish morphology and expressions of genes included in the development of muscle and bone were examined. Using landmark-based geometric morphometrics, we found that environmentally relevant concentrations of TDCIPP altered morphology of female zebrafish. Furthermore, TDCIPP decreased the ratio of caudal fin area to whole body area and muscle density. These effects were possibly resulted from the alteration in the expression of genes included in the development of muscle (myf5 and myog) and bone (bmp2b and bmp4).
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping