PUBLICATION
Impact on growth, oxidative stress, and apoptosis-related gene transcription of zebrafish after exposure to low concentration of arsenite
- Authors
- Dong, W.Q., Sun, H.J., Zhang, Y., Lin, H.J., Chen, J.R., Hong, H.C.
- ID
- ZDB-PUB-180814-4
- Date
- 2018
- Source
- Chemosphere 211: 648-652 (Journal)
- Registered Authors
- Keywords
- Apoptosis, Arsenite, Oxidative damage, Oxidative stress, Zebrafish
- MeSH Terms
-
- Animals
- Apoptosis/genetics*
- Arsenites/chemistry*
- Oxidative Stress
- Zebrafish/genetics*
- PubMed
- 30098560 Full text @ Chemosphere
- CTD
- 30098560
Citation
Dong, W.Q., Sun, H.J., Zhang, Y., Lin, H.J., Chen, J.R., Hong, H.C. (2018) Impact on growth, oxidative stress, and apoptosis-related gene transcription of zebrafish after exposure to low concentration of arsenite. Chemosphere. 211:648-652.
Abstract
Low concentrations of arsenic (As) contamination in aquatic environment is a worldwide issue, which is of great concern. To evaluate the impact of low concentrations of As on zebrafish, we measured the growth, antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT), oxidative damage (malondialdehyde, MDA) and apoptosis-related genes (nrf2, p53 and c-jun) of adult zebrafish after exposing to different AsIII concentrations (0, 10, 50, 100 or 150 μg L-1) for 28 d. Results indicated that exposure to low AsIII concentrations decreased the zebrafish weight by 14%, increased the activities of SOD and CAT by 23-41% and 31-59%, decreased the contents of MDA by 29-54%, and modulated transcription of apoptosis related genes. Our study showed that chronic exposure to AsIII concentrations <150 μg L-1 generated oxidative stress and damage on zebrafish, and altered apoptosis-related genes in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping