PUBLICATION
Characterization of sickness behavior in zebrafish
- Authors
- Kirsten, K., Soares, S.M., Koakoski, G., Carlos Kreutz, L., Barcellos, L.J.G.
- ID
- ZDB-PUB-180710-1
- Date
- 2018
- Source
- Brain, behavior, and immunity 73: 596-602 (Journal)
- Registered Authors
- Keywords
- Brain, Cytokine, Exploratory behavior, Immune system, Social behavior
- MeSH Terms
-
- Animals
- Behavior, Animal/physiology
- Brain/metabolism
- Cytokines/metabolism
- Disease Models, Animal
- Exploratory Behavior/physiology
- Female
- Illness Behavior/physiology*
- Immune System/metabolism
- Interpersonal Relations
- Locomotion/immunology
- Locomotion/physiology
- Male
- Motor Activity/physiology
- Neurons/metabolism
- Zebrafish/immunology*
- Zebrafish/physiology*
- PubMed
- 29981831 Full text @ Brain Behav. Immun.
Citation
Kirsten, K., Soares, S.M., Koakoski, G., Carlos Kreutz, L., Barcellos, L.J.G. (2018) Characterization of sickness behavior in zebrafish. Brain, behavior, and immunity. 73:596-602.
Abstract
In a previous study we showed a clear relationship between immune system and behavior in zebrafish and we hypothesized that the immune system is capable of inducing behavioral changes. To further investigate this subject and to address our main question, here we induced an inflammatory response in one group of fish by the inoculation of formalin-inactivated Aeromonoas hydrophila bacterin and compared their social and exploratory behavior with control groups. After the behavioral tests, we also analyzed the expression of cytokines genes and markers of neuronal activity in fish brain. In the bacterin-inoculated fish, the locomotor activity, social preference and exploratory behavior towards a new object were reduced compared to the control fish while the expression of proinflammatory cytokines in the brain was upregulated. With this study we demonstrated for the first time that the immune system is capable of causing behavioral changes that are consistent with the sickness behavior observed in mammals.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping