ZFIN ID: ZDB-PUB-180624-2
CMA restricted to mammals and birds: myth or reality?
Lescat, L., Herpin, A., Mourot, B., Véron, V., Guiguen, Y., Bobe, J., Seiliez, I.
Date: 2018
Source: Autophagy   14(7): 1267-1270 (Other)
Registered Authors: Bobe, Julien, Seiliez, Iban
Keywords: LAMP2A, RNA-seq, chaperone-mediated autophagy, evolution, fish
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Autophagy*
  • Birds/genetics
  • Birds/metabolism*
  • Gene Expression Regulation
  • Mammals/genetics
  • Mammals/metabolism*
  • Molecular Chaperones/chemistry
  • Molecular Chaperones/genetics
  • Molecular Chaperones/metabolism*
  • RNA, Messenger/genetics
  • RNA, Messenger/metabolism
PubMed: 29929419 Full text @ Autophagy
Chaperone-mediated autophagy (CMA) is a major pathway of lysosomal proteolysis essential for the control of intermediary metabolism. So far, the absence of any identifiable LAMP2A-a necessary and limiting protein for CMA-outside of the tetrapod clade, led to the paradigm that this cellular function was (presumably) restricted to mammals and birds. However, after we identified expressed sequences displaying high sequence homology with the mammalian LAMP2A in several fish species, our findings challenge that view and suggest that CMA likely appeared much earlier during evolution than initially thought. Hence, our results do not only shed an entirely new light on the evolution of CMA, but also bring new perspectives on the possible use of complementary genetic models, such as zebrafish or medaka for studying CMA function from a comparative angle/view.