PUBLICATION
FGIN-1-27, an agonist at translocator protein 18 kDa (TSPO), produces anti-anxiety and anti-panic effects in non-mammalian models
- Authors
- Lima, M.G., Cueto-Escobedo, J., Rodríguez-Landa, J.F., Maximino, C.
- ID
- ZDB-PUB-180427-6
- Date
- 2018
- Source
- Pharmacology, biochemistry, and behavior 171: 66-73 (Journal)
- Registered Authors
- Lima, Monica Gomes, Maximino, Caio
- Keywords
- Anxiety, Benzodiazepines, Fear, Translocator protein 18 kDa, Wall lizard, Zebrafish
- MeSH Terms
-
- Animals
- Anti-Anxiety Agents/pharmacology*
- Anxiety/prevention & control*
- Behavior, Animal/drug effects*
- Diazepam/pharmacology
- Disease Models, Animal
- Female
- Indoleacetic Acids/pharmacology*
- Lizards*
- Male
- Panic/drug effects*
- Zebrafish*
- PubMed
- 29698632 Full text @ Pharmacol. Biochem. Behav.
Citation
Lima, M.G., Cueto-Escobedo, J., Rodríguez-Landa, J.F., Maximino, C. (2018) FGIN-1-27, an agonist at translocator protein 18 kDa (TSPO), produces anti-anxiety and anti-panic effects in non-mammalian models. Pharmacology, biochemistry, and behavior. 171:66-73.
Abstract
FGIN-1-27 is an agonist at the translocator protein 18 kDa (TSPO), a cholesterol transporter that is associated with neurosteroidogenesis. This protein has been identified as a peripheral binding site for benzodiazepines; in anamniotes, however, a second TSPO isoform that is absent in amniotes has been implicated in erythropoiesis. Functional conservation of the central benzodiazepine-binding site located in the GABAA receptors has been demonstrated in anamniotes and amniotes alike; however, it was not previously demonstrated for TSPO. The present investigation explored the behavioral effects of FGIN-1-27 on an anxiety test in zebrafish (Danio rerio, Family: Cyprinide) and on a mixed anxiety/panic test on wall lizards (Tropidurus oreadicus, Family: Tropiduridae). Results showed that FGIN-1-27 reduced anxiety-like behavior in the zebrafish light/dark preference test similar to diazepam, but with fewer sedative effects. Similarly, FGIN-1-27 also reduced anxiety- and fear-like behaviors in the defense test battery in wall lizards, again producing fewer sedative-like effects than diazepam; the benzodiazepine was also unable to reduce fear-like behaviors in this species. These results A) underline the functional conservation of TSPO in defensive behavior in anamniotes; B) strengthen the proposal of using anamniote behavior as models in behavioral pharmacology; and C) suggest TSPO/neurosteroidogenesis as a target in treating anxiety disorders.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping