PUBLICATION
Outside-In Systems Pharmacology Combines Innovative Computational Methods With High-Throughput Whole Vertebrate Studies
- Authors
- Schulthess, P., van Wijk, R.C., Krekels, E.H.J., Yates, J.W.T., Spaink, H.P., van der Graaf, P.H.
- ID
- ZDB-PUB-180426-17
- Date
- 2018
- Source
- CPT: pharmacometrics & systems pharmacology 7(5): 285-287 (Other)
- Registered Authors
- Spaink, Herman P.
- Keywords
- none
- MeSH Terms
-
- Animals
- Computer Simulation
- Drug Discovery/methods*
- Models, Theoretical
- Systems Biology/methods*
- Zebrafish
- PubMed
- 29693322 Full text @ CPT Pharmacometrics Syst Pharmacol
Citation
Schulthess, P., van Wijk, R.C., Krekels, E.H.J., Yates, J.W.T., Spaink, H.P., van der Graaf, P.H. (2018) Outside-In Systems Pharmacology Combines Innovative Computational Methods With High-Throughput Whole Vertebrate Studies. CPT: pharmacometrics & systems pharmacology. 7(5):285-287.
Abstract
To advance the systems approach in pharmacology, experimental models and computational methods need to be integrated from early drug discovery onward. Here, we propose outside-in model development, a model identification technique to understand and predict the dynamics of a system without requiring prior biological and/or pharmacological knowledge. The advanced data required could be obtained by whole vertebrate, high-throughput, low-resource dose-exposure-effect experimentation with the zebrafish larva. Combinations of these innovative techniques could improve early drug discovery.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping