PUBLICATION
[The zebrafish model in oncology]
- Authors
- Völkel, P., Dupret, B., Le Bourhis, X., Angrand, P.O.
- ID
- ZDB-PUB-180418-55
- Date
- 2018
- Source
- Medecine sciences : M/S 34: 345-353 (Review)
- Registered Authors
- Angrand, Pierre-Olivier, Dupret, Barbara, Völkel, Pamela
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Disease Models, Animal*
- Embryo, Nonmammalian
- Humans
- Medical Oncology*/methods
- Medical Oncology*/trends
- Mutagenesis/genetics
- Zebrafish*/embryology
- Zebrafish*/genetics
- PubMed
- 29658479 Full text @ Med. Sci. (Paris)
Citation
Völkel, P., Dupret, B., Le Bourhis, X., Angrand, P.O. (2018) [The zebrafish model in oncology]. Medecine sciences : M/S. 34:345-353.
Abstract
Although cell culture and mouse models will remain a cornerstone of cancer research, the unique capabilities of the zebrafish outline the potential of this model for shedding light on cancer biology in vivo. Zebrafish develops cancers spontaneously, after chemical mutagenesis or through genetic manipulations. Furthermore, zebrafish cancers are similar to human tumors at the histological and molecular levels allowing the study of tumor initiation, progression and heterogeneity. Xenotransplantation of human cancer cells in embryos or adult zebrafish presents the advantage of following cancer cell behavior in vivo. Finally, zebrafish embryos are used in molecule screens and contribute to the identification of novel anti-cancer therapeutic strategies. Here, we review different involvements of the zebrafish model in cancer research.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping