PUBLICATION
Early life exposure of zebrafish (Danio rerio) to synthetic pyrethroids and their metabolites: a comparison of phenotypic and behavioral indicators and gene expression involved in the HPT axis and innate immune system
- Authors
- Xu, C., Li, X., Jin, M., Sun, X., Niu, L., Lin, C., Liu, W.
- ID
- ZDB-PUB-180227-8
- Date
- 2018
- Source
- Environmental science and pollution research international 25(13): 12992-13003 (Journal)
- Registered Authors
- Keywords
- Innate immune, Locomotor activity, Metabolites, Pyrethroids, Thyroid disrupter, Zebrafish
- MeSH Terms
-
- Animals
- Behavior, Animal/drug effects*
- Embryo, Nonmammalian/drug effects
- Embryonic Development/drug effects*
- Embryonic Development/genetics
- Embryonic Development/immunology
- Gene Expression/drug effects*
- Hypothalamo-Hypophyseal System/drug effects
- Hypothalamo-Hypophyseal System/immunology
- Immunity, Innate/drug effects*
- Immunity, Innate/genetics
- Larva/drug effects
- Motor Activity/drug effects
- Motor Activity/immunology
- Pyrethrins/metabolism
- Pyrethrins/toxicity*
- Thyroid Gland/drug effects
- Thyroid Gland/immunology
- Water Pollutants, Chemical/metabolism
- Water Pollutants, Chemical/toxicity*
- Zebrafish/genetics
- Zebrafish/growth & development*
- Zebrafish/immunology
- PubMed
- 29480392 Full text @ Environ. Sci. Pollut. Res. Int.
Citation
Xu, C., Li, X., Jin, M., Sun, X., Niu, L., Lin, C., Liu, W. (2018) Early life exposure of zebrafish (Danio rerio) to synthetic pyrethroids and their metabolites: a comparison of phenotypic and behavioral indicators and gene expression involved in the HPT axis and innate immune system. Environmental science and pollution research international. 25(13):12992-13003.
Abstract
Ecotoxicological studies have revealed the association between synthetic pyrethroid (SP) exposure and aquatic toxicity in fish; however, research on the toxic effects of SP metabolites is still limited. In this study, the toxicity of two SPs (permethrin (PM) and β-cypermethrin (β-CP)) and their three metabolites (3-phenoxybenzoic alcohol (PBCOH), 3-phenoxybenzaldehyde (PBCHO), and 3-phenoxybenzoic acid (PBCOOH)) towards zebrafish embryos and larvae was evaluated. Both SPs and their metabolites exhibited significant developmental toxicities, caused abnormal vascular development, and changed locomotor activities in larvae. The alteration of gene expression involved in the thyroid system and the innate immune system indicated that SPs and their three metabolites have the potency to induce thyroid disruption and trigger an immune response. The results from the present study suggest that SP metabolites could induce multiple toxic responses similar to parent compounds, and their toxicity should be considered for improving the understanding of environmental risks of SPs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping