PUBLICATION
Developmental toxicity of penconazole in Zebrfish (Danio rerio) embryos
- Authors
- Icoglu Aksakal, F., Ciltas, A.
- ID
- ZDB-PUB-180223-65
- Date
- 2018
- Source
- Chemosphere 200: 8-15 (Journal)
- Registered Authors
- Keywords
- Developmental toxicity, Hatching, Malformation, Penconazole, Zebrafish embryo, mRNA level
- MeSH Terms
-
- Animals
- Dose-Response Relationship, Drug
- Ecotoxicology
- Embryo, Nonmammalian/drug effects*
- Embryo, Nonmammalian/embryology*
- Embryo, Nonmammalian/metabolism
- Gene Expression Regulation, Developmental/drug effects
- Triazoles/toxicity*
- Zebrafish/embryology*
- Zebrafish Proteins/genetics
- PubMed
- 29471168 Full text @ Chemosphere
Citation
Icoglu Aksakal, F., Ciltas, A. (2018) Developmental toxicity of penconazole in Zebrfish (Danio rerio) embryos. Chemosphere. 200:8-15.
Abstract
Penconazole is a widely used fungicide that is toxic to a variety of organisms including fish. In the present study, we investigated the developmental toxicity of penconazole on zebrafish embryos by exposing to different concentrations of penconazole (0.8, 1.6 and 2.4 mg/L) from 4-h post-fertilization (hpf). Hatching, survival, and heart rates, body length, malformation and expression of several genes were detected. The results showed that penconazole exposure induced developmental toxicity, including delayed hatching, reduced survival, and heart rate. In addition to this, exposure to penconazole caused malformations, including pericardial edema, yolk sac edema, axial malformation, tail malformation and spinal curvature. Furthermore, RT-PCR results showed that mRNA levels of antioxidant genes were down-regulated after penconazole exposure. On the other hand, mRNA levels of interleukin 1 beta and interferon in embryos were up-regulated after exposure to penconazole. In summary, our data indicated that penconazole cause embryonic development toxicity on zebrafish embryos.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping