PUBLICATION
Widening control of fin inter-rays in zebrafish and inferences about actinopterygian fins
- Authors
- Murciano, C., Cazorla-Vázquez, S., Gutiérrez, J., Hijano, J.A., Ruiz-Sánchez, J., Mesa-Almagro, L., Martín-Reyes, F., Fernández, T.D., Marí-Beffa, M.
- ID
- ZDB-PUB-180223-6
- Date
- 2018
- Source
- Journal of anatomy 232(5): 783-805 (Journal)
- Registered Authors
- Marí-Beffa, Manuel
- Keywords
- knck5b, actinopterygii, euteleostei, evo-devo, fibroblast growth factor receptor 1, fin regeneration, inter-ray
- MeSH Terms
-
- Animal Fins/anatomy & histology
- Animal Fins/physiology*
- Animals
- Animals, Genetically Modified
- Cell Movement
- Female
- Gene Expression
- Hedgehog Proteins/metabolism
- Male
- Potassium Channels, Tandem Pore Domain/metabolism
- Receptor, Fibroblast Growth Factor, Type 1/metabolism
- Regeneration*
- Zebrafish/anatomy & histology
- Zebrafish/physiology*
- Zebrafish Proteins/metabolism
- PubMed
- 29441573 Full text @ J. Anat.
Citation
Murciano, C., Cazorla-Vázquez, S., Gutiérrez, J., Hijano, J.A., Ruiz-Sánchez, J., Mesa-Almagro, L., Martín-Reyes, F., Fernández, T.D., Marí-Beffa, M. (2018) Widening control of fin inter-rays in zebrafish and inferences about actinopterygian fins. Journal of anatomy. 232(5):783-805.
Abstract
The amputation of a teleost fin rapidly triggers an intricate maze of hierarchically regulated signalling processes which ultimately reconstruct the diverse tissues of the appendage. Whereas the generation of the fin pattern along the proximodistal axis brings with it several well-known developmental regulators, the mechanisms by which the fin widens along its dorsoventral axis remain poorly understood. Utilizing the zebrafish as an experimental model of fin regeneration and studying more than 1000 actinopterygian species, we hypothesized a connection between specific inter-ray regulatory mechanisms and the morphological variability of inter-ray membranes found in nature. To tackle these issues, both cellular and molecular approaches have been adopted and our results suggest the existence of two distinguishable inter-ray areas in the zebrafish caudal fin, a marginal and a central region. The present work associates the activity of the cell membrane potassium channel kcnk5b, the fibroblast growth factor receptor 1 and the sonic hedgehog pathway to the control of several cell functions involved in inter-ray wound healing or dorsoventral regeneration of the zebrafish caudal fin. This ray-dependent regulation controls cell migration, cell-type patterning and gene expression. The possibility that modifications of these mechanisms are responsible for phenotypic variations found in euteleostean species, is discussed.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping