PUBLICATION
First description of behavior and immune system relationship in fish
- Authors
- Kirsten, K., Fior, D., Kreutz, L.C., Barcellos, L.J.G.
- ID
- ZDB-PUB-180118-16
- Date
- 2018
- Source
- Scientific Reports 8: 846 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Exploratory Behavior*
- Female
- Immune System/metabolism*
- Interferon-gamma/genetics
- Interferon-gamma/metabolism
- Interleukin-10/genetics
- Interleukin-10/metabolism
- Interleukin-1beta/genetics
- Male
- Transcriptome
- Zebrafish/metabolism*
- PubMed
- 29339805 Full text @ Sci. Rep.
Citation
Kirsten, K., Fior, D., Kreutz, L.C., Barcellos, L.J.G. (2018) First description of behavior and immune system relationship in fish. Scientific Reports. 8:846.
Abstract
Considering the intriguing relationship between immune system and behavior recently described in mammals, and the lack of information of this relationship in fish, here we describe for the first time the interaction between the immune system and social and exploratory behavior in zebrafish. Fish high responders to novelty (HRN) presented a proinflammatory profile, with increased IL-1β and reduced IL-10 expression compared to fish low responders to novelty (LRN). Likewise, fish less responsive to social stimuli have a reduced expression of INF-γ. We show that fish with different behavior patterns have differences in the immune response. Our findings indicate that the interplay between immune system and behavior in zebrafish is similar to that found in mammalian models and that zebrafish should be considered as a potential model organism to study the relationship between immune system and behavior.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping