PUBLICATION

The function of endocytosis in Wnt signaling.

Authors
Brunt, L., Scholpp, S.
ID
ZDB-PUB-171229-7
Date
2017
Source
Cellular and molecular life sciences : CMLS   75(5): 785-795 (Review)
Registered Authors
Brunt, Lucy, Scholpp, Steffen
Keywords
Cytonemes, Endocytosis, Exosomes, Planar cell polarity, Signal activation, Wnt
MeSH Terms
  • Animals
  • Endocytosis/physiology*
  • Humans
  • Protein Transport/physiology
  • Wnt Signaling Pathway*
  • beta Catenin/physiology
PubMed
28913633 Full text @ Cell. Mol. Life Sci.
Abstract

Wnt growth factors regulate one of the most important signaling networks during development, tissue homeostasis and disease. Despite the biological importance of Wnt signaling, the mechanism of endocytosis during this process is ill described. Wnt molecules can act as paracrine signals, which are secreted from the producing cells and transported through neighboring tissue to activate signaling in target cells. Endocytosis of the ligand is important at several stages of action: One central function of endocytic trafficking in the Wnt pathway occurs in the source cell. Furthermore, the β-catenin-dependent Wnt ligands require endocytosis for signal activation and to regulate gene transcription in the responding cells. Alternatively, Wnt/β-catenin-independent signaling regulates endocytosis of cell adherence plaques to control cell migration. In this comparative review, we elucidate these three fundamental interconnected functions, which together regulate cellular fate and cellular behavior. Based on established hypotheses and recent findings, we develop a revised picture for the complex function of endocytosis in the Wnt signaling network.

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