ZFIN ID: ZDB-PUB-171206-12
Developmental HSC Microenvironments: Lessons from Zebrafish
Nik, S., Weinreb, J.T., Bowman, T.V.
Date: 2017
Source: Advances in experimental medicine and biology   1041: 33-53 (Chapter)
Registered Authors: Bowman, Teresa
Keywords: Blood development, Hematopoietic niche, Hematopoietic stem cell, Zebrafish
MeSH Terms:
  • Animals
  • Body Patterning/physiology*
  • Cell Movement/physiology*
  • Embryo, Nonmammalian/cytology
  • Embryo, Nonmammalian/embryology
  • Hematopoietic Stem Cells/cytology
  • Hematopoietic Stem Cells/physiology*
  • Humans
  • Signal Transduction/physiology*
  • Stem Cell Niche/physiology*
  • Time Factors
  • Zebrafish/embryology
PubMed: 29204828 Full text @ Adv. Exp. Med. Biol.
Hematopoietic stem cells (HSCs) posses the ability to maintain the blood system of an organism from birth to adulthood. The behavior of HSCs is modulated by its microenvironment. During development, HSCs acquire the instructions to self-renew and differentiate into all blood cell fates by passing through several developmental microenvironments. In this chapter, we discuss the signals and cell types that inform HSC decisions throughout ontogeny with a focus on HSC specification, mobilization, migration, and engraftment.