PUBLICATION
Sensorimotor computation underlying phototaxis in zebrafish
- Authors
- Wolf, S., Dubreuil, A.M., Bertoni, T., Böhm, U.L., Bormuth, V., Candelier, R., Karpenko, S., Hildebrand, D.G.C., Bianco, I.H., Monasson, R., Debrégeas, G.
- ID
- ZDB-PUB-170923-6
- Date
- 2017
- Source
- Nature communications 8: 651 (Journal)
- Registered Authors
- Bianco, Isaac
- Keywords
- Dynamical systems, Navigation, Neural circuits, Saccades, Sensory processing
- MeSH Terms
-
- Animals
- Behavior, Animal/radiation effects
- Larva/physiology
- Larva/radiation effects
- Light
- Locomotion/radiation effects
- Models, Biological
- Neurons/physiology
- Neurons/radiation effects
- Phototaxis/radiation effects*
- Rhombencephalon/physiology
- Rhombencephalon/radiation effects
- Zebrafish/physiology*
- PubMed
- 28935857 Full text @ Nat. Commun.
Citation
Wolf, S., Dubreuil, A.M., Bertoni, T., Böhm, U.L., Bormuth, V., Candelier, R., Karpenko, S., Hildebrand, D.G.C., Bianco, I.H., Monasson, R., Debrégeas, G. (2017) Sensorimotor computation underlying phototaxis in zebrafish. Nature communications. 8:651.
Abstract
Animals continuously gather sensory cues to move towards favourable environments. Efficient goal-directed navigation requires sensory perception and motor commands to be intertwined in a feedback loop, yet the neural substrate underlying this sensorimotor task in the vertebrate brain remains elusive. Here, we combine virtual-reality behavioural assays, volumetric calcium imaging, optogenetic stimulation and circuit modelling to reveal the neural mechanisms through which a zebrafish performs phototaxis, i.e. actively orients towards a light source. Key to this process is a self-oscillating hindbrain population (HBO) that acts as a pacemaker for ocular saccades and controls the orientation of successive swim-bouts. It further integrates visual stimuli in a state-dependent manner, i.e. its response to visual inputs varies with the motor context, a mechanism that manifests itself in the phase-locked entrainment of the HBO by periodic stimuli. A rate model is developed that reproduces our observations and demonstrates how this sensorimotor processing eventually biases the animal trajectory towards bright regions.Active locomotion requires closed-loop sensorimotor co ordination between perception and action. Here the authors show using behavioural, imaging and modelling approaches that gaze orientation during phototaxis behaviour in larval zebrafish is related to oscillatory dynamics of a neuronal population in the hindbrain.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping