ZFIN ID: ZDB-PUB-170907-13
The FaceBase Consortium: a comprehensive resource for craniofacial researchers
Brinkley, J.F., Fisher, S., Harris, M.P., Holmes, G., Hooper, J.E., Jabs, E.W., Jones, K.L., Kesselman, C., Klein, O.D., Maas, R.L., Marazita, M.L., Selleri, L., Spritz, R.A., van Bakel, H., Visel, A., Williams, T.J., Wysocka, J., Chai, Y.
Date: 2016
Source: Development (Cambridge, England)   143: 2677-88 (Other)
Registered Authors: Fisher, Shannon, Harris, Matthew
Keywords: Craniofacial development, Data resource, FaceBase Consortium
MeSH Terms:
  • Animals
  • Chromatin Immunoprecipitation
  • Computational Biology
  • Databases, Factual*
  • Face/embryology*
  • Genomics
  • Humans
  • Mice
  • Models, Animal
  • Research Personnel*
  • Skull/embryology*
  • Zebrafish
PubMed: 27287806 Full text @ Development
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ABSTRACT
The FaceBase Consortium, funded by the National Institute of Dental and Craniofacial Research, National Institutes of Health, is designed to accelerate understanding of craniofacial developmental biology by generating comprehensive data resources to empower the research community, exploring high-throughput technology, fostering new scientific collaborations among researchers and human/computer interactions, facilitating hypothesis-driven research and translating science into improved health care to benefit patients. The resources generated by the FaceBase projects include a number of dynamic imaging modalities, genome-wide association studies, software tools for analyzing human facial abnormalities, detailed phenotyping, anatomical and molecular atlases, global and specific gene expression patterns, and transcriptional profiling over the course of embryonic and postnatal development in animal models and humans. The integrated data visualization tools, faceted search infrastructure, and curation provided by the FaceBase Hub offer flexible and intuitive ways to interact with these multidisciplinary data. In parallel, the datasets also offer unique opportunities for new collaborations and training for researchers coming into the field of craniofacial studies. Here, we highlight the focus of each spoke project and the integration of datasets contributed by the spokes to facilitate craniofacial research.
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