PUBLICATION
Protective Effects of Xylose-Taurine Reduced against Damages Caused by Oxidative Stress in Zebrafish Embryos In Vivo Model
- Authors
- Lee, W., Kim, E.A., Um, J.H., Kang, N., Oh, J.Y., Park, S.Y., Han, E.J., Cheong, S.H., Chang, K.J., Kim, S.H., Ahn, C.B., Jeon, Y.J., Ahn, G.
- ID
- ZDB-PUB-170830-9
- Date
- 2017
- Source
- Advances in experimental medicine and biology 975: 643-653 (Journal)
- Registered Authors
- Jeon, You-Jin
- Keywords
- Oxidative stress, Protective effects, Xylose-Taurine reduced, Zebrafish embryos
- MeSH Terms
-
- Animals
- Antioxidants/pharmacology*
- Apoptosis/drug effects
- Embryo, Nonmammalian
- Oxidative Stress/drug effects*
- Protective Agents/pharmacology
- Taurine/pharmacology*
- Xylose/pharmacology*
- Zebrafish
- PubMed
- 28849488 Full text @ Adv. Exp. Med. Biol.
Citation
Lee, W., Kim, E.A., Um, J.H., Kang, N., Oh, J.Y., Park, S.Y., Han, E.J., Cheong, S.H., Chang, K.J., Kim, S.H., Ahn, C.B., Jeon, Y.J., Ahn, G. (2017) Protective Effects of Xylose-Taurine Reduced against Damages Caused by Oxidative Stress in Zebrafish Embryos In Vivo Model. Advances in experimental medicine and biology. 975:643-653.
Abstract
The zebrafish (Danio rerio) is useful and convenient vertebrate models in various studies in human disease and drug discovery. In this present study, we first evaluated whether Xylose-Taurine reduced (X-T-R), a taurine derivate protects zebrafish embryos against oxidative stress caused by AAPH (2,2'-Azobis(2-amidinopropane) dihydrochloride). First of all, we selected the concentration of X-T-R showing no toxicity in zebrafish embryos. We identified that X-T-R significantly increased the survival of zebrafish embryo reduced by treatment of AAPH. Also, X-T-R effectively inhibited the productions of reactive oxygen species (ROS) and nitric oxide (NO) as well as the formation of cell death in zebrafish embryos. Moreover, X-T-R down-regulated the expression levels of Bax, caspase-3, caspase-9 and p53 known as pro-apoptotic molecules, whereas up-regulated those of Bcl-2, an anti-apoptotic molecule in AAPH-treated zebrafish embryos. From these results, this study reveals that X-T-R, a taurine derivate might be a potential protector against various damages caused by oxidative stress.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping