ZFIN ID: ZDB-PUB-170829-9
The Chordin Morphogenetic Pathway
De Robertis, E.M., Moriyama, Y.
Date: 2016
Source: Current topics in developmental biology   116: 231-45 (Chapter)
Registered Authors: De Robertis, Eddy
Keywords: BMP, Chordin, Gradient, Morphogen, Self-organization, Sizzled, Tolloid
MeSH Terms:
  • Animals
  • Bone Morphogenetic Proteins/metabolism*
  • Cloning, Molecular
  • Drosophila Proteins/genetics
  • Drosophila Proteins/metabolism
  • Embryo, Nonmammalian
  • GTPase-Activating Proteins/genetics
  • GTPase-Activating Proteins/metabolism
  • Glycoproteins/genetics
  • Glycoproteins/metabolism*
  • Intercellular Signaling Peptides and Proteins/genetics
  • Intercellular Signaling Peptides and Proteins/metabolism*
  • Morphogenesis/physiology*
  • Signal Transduction
  • Tolloid-Like Metalloproteinases/genetics
  • Tolloid-Like Metalloproteinases/metabolism
  • Xenopus/embryology
  • Xenopus/metabolism
  • Xenopus Proteins/genetics
  • Xenopus Proteins/metabolism
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed: 26970622 Full text @ Curr. Top. Dev. Biol.
The ancestral Chordin/bone morphogenetic protein (BMP) signaling pathway that establishes dorsal-ventral (D-V) patterning in animal development is one of the best understood morphogenetic gradients, and is established by multiple proteins that interact with each other in the extracellular space-including several BMPs, Chordin, Tolloid, Ont-1, Crossveinless-2, and Sizzled. The D-V gradient is adjusted redundantly by regulating the synthesis of its components, by direct protein-protein interactions between morphogens, and by long-range diffusion. The entire embryo participates in maintaining the D-V BMP gradient, so that for each action in the dorsal side there is a reaction in the ventral side. A gradient of Chordin is formed in the extracellular matrix that separates ectoderm from endomesoderm, called Brachet's cleft in Xenopus. The Chordin/BMP pathway is self-organizing and able to scale pattern in the dorsal half of bisected embryos or in Spemann dorsal lip transplantation experiments.