PUBLICATION
Parental exposure to bisphenol A and its analogs influences zebrafish offspring immunity
- Authors
- Dong, X., Zhang, Z., Meng, S., Pan, C., Yang, M., Wu, X., Yang, L., Xu, H.
- ID
- ZDB-PUB-170815-4
- Date
- 2018
- Source
- The Science of the total environment 610-611: 291-297 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Benzhydryl Compounds/adverse effects*
- Female
- Larva/drug effects
- Larva/immunology
- Male
- Maternal Exposure/adverse effects*
- Paternal Exposure/adverse effects*
- Phenols/adverse effects*
- Water Pollutants, Chemical/adverse effects*
- Zebrafish/immunology*
- PubMed
- 28806546 Full text @ Sci. Total Environ.
- CTD
- 28806546
Citation
Dong, X., Zhang, Z., Meng, S., Pan, C., Yang, M., Wu, X., Yang, L., Xu, H. (2018) Parental exposure to bisphenol A and its analogs influences zebrafish offspring immunity. The Science of the total environment. 610-611:291-297.
Abstract
Transgenerational effects of environmental pollutants on humans and animals are complex. Thus, we used zebrafish to evaluate the effects of parental whole-life cycle exposure to bisphenol A and its analogs (bisphenol S and F) on offspring innate immunity. At adulthood, offspring were examined with/without continued chemicals treatment until 72h post-fertilization (hpf). To measure offspring immune function, larvae at 72 hpf were expose for 24h with/without the viral mimic polyinosinic-cytidylic acid (Poly I:C) or the bacterial mimic Pam3Cys-Ser-Lys4 (PAM3CSK4). Data show modified immunity in offspring. Specifically, lysozyme activity was significantly induced in F1 larvae and respiratory burst response and oxidative defense genes were inhibited. Genes of the innate immune system including Toll-like receptors and their downstream molecules and inflammatory cytokines were significantly down-regulated, whereas matrix metalloproteinases were up-regulated in larvae. In addition, recombination-activating genes in the immature adaptive immune system were significantly reduced. Thus, immune defense is diminished by exposing parental generations of zebrafish to environmentally relevant concentration of bisphenols and this suggests that fish chronically exposed to bisphenols in the wild may be vulnerable to pathogens.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping