Neveu, P., Sinha, D., Kettunen, P., Vriz, S., Julien, L., Bensimon, D. (2010) Single cell physiology. Proceedings of the Nobel Symposium on Single Molecule Spectroscopy in Chemistry, Physics and Biology. 96:305-316.
Summary. The possibility to control at specific times and specific places the
activity of biomolecules (enzymes, transcription factors, RNA, hormones, etc.) is
opening up new opportunities in the study of physiological processes at the single
cell level in a live organism. Most existing gene expression systems allow for tissue
specific induction upon feeding the organism with exogenous inducers (e.g., tetracycline).
Local genetic control has earlier been achieved by micro-injection of the
relevant inducer/repressor molecule, but this is an invasive and possibly traumatic
technique. In this chapter, we present the requirements for a noninvasive optical
control of the activity of biomolecules and review the recent advances in this new
field of research.
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