PUBLICATION
c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/β-Catenin/Axin2 Pathway
- Authors
- Li, Y., Jin, K., van Pelt, G.W., van Dam, H., Yu, X., Mesker, W.E., Ten Dijke, P., Zhou, F., Zhang, L.
- ID
- ZDB-PUB-170729-8
- Date
- 2016
- Source
- Cancer research 76: 3364-75 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Apoptosis
- Axin Protein/genetics
- Axin Protein/metabolism*
- Biomarkers, Tumor/genetics
- Biomarkers, Tumor/metabolism
- Blotting, Western
- Breast Neoplasms/genetics
- Breast Neoplasms/metabolism
- Breast Neoplasms/pathology*
- Cell Proliferation
- Embryo, Nonmammalian/cytology
- Embryo, Nonmammalian/metabolism
- Female
- Humans
- Immunoenzyme Techniques
- Lung Neoplasms/genetics
- Lung Neoplasms/metabolism
- Lung Neoplasms/secondary*
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neoplasm Invasiveness
- Neoplasm Staging
- Prognosis
- Proto-Oncogene Proteins c-myb/genetics
- Proto-Oncogene Proteins c-myb/metabolism*
- RNA, Messenger/genetics
- Real-Time Polymerase Chain Reaction
- Reverse Transcriptase Polymerase Chain Reaction
- Tumor Cells, Cultured
- Wnt1 Protein/genetics
- Wnt1 Protein/metabolism*
- Xenograft Model Antitumor Assays
- Zebrafish/genetics
- Zebrafish/growth & development
- Zebrafish/metabolism
- beta Catenin/genetics
- beta Catenin/metabolism*
- PubMed
- 27197202 Full text @ Cancer Res.
Citation
Li, Y., Jin, K., van Pelt, G.W., van Dam, H., Yu, X., Mesker, W.E., Ten Dijke, P., Zhou, F., Zhang, L. (2016) c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/β-Catenin/Axin2 Pathway. Cancer research. 76:3364-75.
Abstract
The molecular underpinnings of aggressive breast cancers remain mainly obscure. Here we demonstrate that activation of the transcription factor c-Myb is required for the prometastatic character of basal breast cancers. An analysis of breast cancer patients led us to identify c-Myb as an activator of Wnt/β-catenin signaling. c-Myb interacted with the intracellular Wnt effector β-catenin and coactivated the Wnt/β-catenin target genes Cyclin D1 and Axin2 Moreover, c-Myb controlled metastasis in an Axin2-dependent manner. Expression microarray analyses revealed a positive association between Axin2 and c-Myb, a target of the proinflammatory cytokine IL1β that was found to be required for IL1β-induced breast cancer cell invasion. Overall, our results identified c-Myb as a promoter of breast cancer invasion and metastasis through its ability to activate Wnt/β-catenin/Axin2 signaling. Cancer Res; 76(11); 3364-75. ©2016 AACR.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping