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ZFIN ID: ZDB-PUB-170729-8
c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/β-Catenin/Axin2 Pathway
Li, Y., Jin, K., van Pelt, G.W., van Dam, H., Yu, X., Mesker, W.E., Ten Dijke, P., Zhou, F., Zhang, L.
Date: 2016
Source: Cancer research   76: 3364-75 (Journal)
Registered Authors:
Keywords: none
MeSH Terms:
  • Animals
  • Apoptosis
  • Axin Protein/genetics
  • Axin Protein/metabolism*
  • Biomarkers, Tumor/genetics
  • Biomarkers, Tumor/metabolism
  • Blotting, Western
  • Breast Neoplasms/genetics
  • Breast Neoplasms/metabolism
  • Breast Neoplasms/pathology*
  • Cell Proliferation
  • Embryo, Nonmammalian/cytology
  • Embryo, Nonmammalian/metabolism
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Lung Neoplasms/genetics
  • Lung Neoplasms/metabolism
  • Lung Neoplasms/secondary*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Neoplasm Invasiveness
  • Neoplasm Staging
  • Prognosis
  • Proto-Oncogene Proteins c-myb/genetics
  • Proto-Oncogene Proteins c-myb/metabolism*
  • RNA, Messenger/genetics
  • Real-Time Polymerase Chain Reaction
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tumor Cells, Cultured
  • Wnt1 Protein/genetics
  • Wnt1 Protein/metabolism*
  • Xenograft Model Antitumor Assays
  • Zebrafish/genetics
  • Zebrafish/growth & development
  • Zebrafish/metabolism
  • beta Catenin/genetics
  • beta Catenin/metabolism*
PubMed: 27197202 Full text @ Cancer Res.
The molecular underpinnings of aggressive breast cancers remain mainly obscure. Here we demonstrate that activation of the transcription factor c-Myb is required for the prometastatic character of basal breast cancers. An analysis of breast cancer patients led us to identify c-Myb as an activator of Wnt/β-catenin signaling. c-Myb interacted with the intracellular Wnt effector β-catenin and coactivated the Wnt/β-catenin target genes Cyclin D1 and Axin2 Moreover, c-Myb controlled metastasis in an Axin2-dependent manner. Expression microarray analyses revealed a positive association between Axin2 and c-Myb, a target of the proinflammatory cytokine IL1β that was found to be required for IL1β-induced breast cancer cell invasion. Overall, our results identified c-Myb as a promoter of breast cancer invasion and metastasis through its ability to activate Wnt/β-catenin/Axin2 signaling. Cancer Res; 76(11); 3364-75. ©2016 AACR.