PUBLICATION

Zebrafish Get Connected: Investigating Neurotransmission Targets and Alterations in Chemical Toxicity

Authors
Horzmann, K.A., Freeman, J.L.
ID
ZDB-PUB-170722-3
Date
2016
Source
Toxics   4(3): (Review)
Registered Authors
Freeman, Jennifer
Keywords
GABA, acetylcholine, dopamine, glutamate, neurotoxicology, neurotransmission, neurotransmitters, norepinephrine, serotonin, zebrafish
MeSH Terms
none
PubMed
28730152 Full text @ Toxics
Abstract
Neurotransmission is the basis of neuronal communication and is critical for normal brain development, behavior, learning, and memory. Exposure to drugs and chemicals can alter neurotransmission, often through unknown pathways and mechanisms. The zebrafish (Danio rerio) model system is increasingly being used to study the brain and chemical neurotoxicity. In this review, the major neurotransmitter systems, including glutamate, GABA, dopamine, norepinephrine, serotonin, acetylcholine, histamine, and glutamate are surveyed and pathways of synthesis, transport, metabolism, and action are examined. Differences between human and zebrafish neurochemical pathways are highlighted. We also review techniques for evaluating neurological function, including the measurement of neurotransmitter levels, assessment of gene expression through transcriptomic analysis, and the recording of neurobehavior. Finally examples of chemical toxicity studies evaluating alterations in neurotransmitter systems in the zebrafish model are reviewed.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes