PUBLICATION
Genetic compensation: A phenomenon in search of mechanisms
- Authors
- El-Brolosy, M.A., Stainier, D.Y.R.
- ID
- ZDB-PUB-170714-4
- Date
- 2017
- Source
- PLoS Genetics 13: e1006780 (Review)
- Registered Authors
- Stainier, Didier
- Keywords
- none
- MeSH Terms
-
- Transcription, Genetic*
- Mice
- Zebrafish/genetics
- Dosage Compensation, Genetic*
- Models, Animal
- Mutant Proteins/biosynthesis
- Mutant Proteins/genetics
- Gene Knockout Techniques*
- Arabidopsis/genetics
- Zebrafish Proteins/genetics
- Gene Knockdown Techniques*
- Animals
- Drosophila/genetics
- PubMed
- 28704371 Full text @ PLoS Genet.
Citation
El-Brolosy, M.A., Stainier, D.Y.R. (2017) Genetic compensation: A phenomenon in search of mechanisms. PLoS Genetics. 13:e1006780.
Abstract
Several recent studies in a number of model systems including zebrafish, Arabidopsis, and mouse have revealed phenotypic differences between knockouts (i.e., mutants) and knockdowns (e.g., antisense-treated animals). These differences have been attributed to a number of reasons including off-target effects of the antisense reagents. An alternative explanation was recently proposed based on a zebrafish study reporting that genetic compensation was observed in egfl7 mutant but not knockdown animals. Dosage compensation was first reported in Drosophila in 1932, and genetic compensation in response to a gene knockout was first reported in yeast in 1969. Since then, genetic compensation has been documented many times in a number of model organisms; however, our understanding of the underlying molecular mechanisms remains limited. In this review, we revisit studies reporting genetic compensation in higher eukaryotes and outline possible molecular mechanisms, which may include both transcriptional and posttranscriptional processes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping