PUBLICATION
An Adenosine Receptor for Olfaction in Fish
- Authors
- Wakisaka, N., Miyasaka, N., Koide, T., Masuda, M., Hiraki-Kajiyama, T., Yoshihara, Y.
- ID
- ZDB-PUB-170516-5
- Date
- 2017
- Source
- Current biology : CB 27(10): 1437-1447.e4 (Journal)
- Registered Authors
- Keywords
- ATP, adenosine receptor, aquatic vertebrates, attraction, ecto-nucleotidase, food searching, olfaction, zebrafish
- MeSH Terms
-
- Adenosine/metabolism
- Adenosine Triphosphatases/metabolism
- Adenosine Triphosphate/metabolism*
- Animals
- Behavior, Animal
- Calcium/metabolism
- Nose/physiology
- Olfactory Mucosa/cytology
- Olfactory Mucosa/physiology
- Olfactory Receptor Neurons/cytology
- Olfactory Receptor Neurons/physiology*
- Phylogeny
- Receptors, Purinergic P1/metabolism
- Smell/physiology*
- Zebrafish/physiology*
- PubMed
- 28502661 Full text @ Curr. Biol.
Citation
Wakisaka, N., Miyasaka, N., Koide, T., Masuda, M., Hiraki-Kajiyama, T., Yoshihara, Y. (2017) An Adenosine Receptor for Olfaction in Fish. Current biology : CB. 27(10):1437-1447.e4.
Abstract
Nucleotides released from food sources into environmental water are supposed to act as feeding cues for many fish species. However, it remains unknown how fish can sensitively detect those nucleotides. Here we discover a novel olfactory mechanism for ATP sensing in zebrafish. Upon entering into the nostril, ATP is efficiently converted into adenosine through enzymatic reactions of two ecto-nucleotidases expressed in the olfactory epithelium. Adenosine subsequently activates a small population of olfactory sensory neurons expressing a novel adenosine receptor A2c that is unique to fishes and amphibians. The information is then transmitted to a single glomerulus in the olfactory bulb and further to four regions in higher olfactory centers. These results provide conclusive evidence for a sophisticated enzyme-linked receptor mechanism underlying detection of ATP as a food-derived attractive odorant linking to foraging behavior that is crucial and common to aquatic lower vertebrates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping