Bipotent progenitors as embryonic origin of retinal stem cells
- Tang, X., Gao, J., Jia, X., Zhao, W., Zhang, Y., Pan, W., He, J.
- The Journal of cell biology 216(6): 1833 (Journal)
- Registered Authors
- He, Jie, Jia, Xinling, Pan, Weijun, Tang, Xia
- MeSH Terms
- Animals, Genetically Modified
- Cell Differentiation*
- Cell Lineage*
- Cell Proliferation
- Embryo, Nonmammalian/metabolism
- Embryo, Nonmammalian/physiology
- Embryonic Stem Cells/metabolism
- Embryonic Stem Cells/physiology*
- Gene Expression Regulation, Developmental
- Retinal Vessels/embryology
- Retinal Vessels/physiology
- Stem Cell Niche
- Time Factors
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- 28465291 Full text @ J. Cell Biol.
Tang, X., Gao, J., Jia, X., Zhao, W., Zhang, Y., Pan, W., He, J. (2017) Bipotent progenitors as embryonic origin of retinal stem cells. The Journal of cell biology. 216(6):1833.
In lower vertebrates, retinal stem cells (RSCs) capable of producing all retinal cell types are a resource for retinal tissue growth throughout life. However, the embryonic origin of RSCs remains largely elusive. Using a Zebrabow-based clonal analysis, we characterized the RSC niche in the ciliary marginal zone of zebrafish retina and illustrate that blood vessels associated with RSCs are required for the maintenance of actively proliferating RSCs. Full lineage analysis of RSC progenitors reveals lineage patterns of RSC production. Moreover, in vivo lineage analysis demonstrates that these RSC progenitors are the direct descendants of a set of bipotent progenitors in the medial epithelial layer of developing optic vesicles, suggesting the involvement of the mixed-lineage states in the RSC lineage specification.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes