PUBLICATION
Bipotent progenitors as embryonic origin of retinal stem cells
- Authors
- Tang, X., Gao, J., Jia, X., Zhao, W., Zhang, Y., Pan, W., He, J.
- ID
- ZDB-PUB-170504-9
- Date
- 2017
- Source
- The Journal of cell biology 216(6): 1833 (Journal)
- Registered Authors
- He, Jie, Jia, Xinling, Pan, Weijun, Tang, Xia
- Keywords
- none
- MeSH Terms
-
- Embryo, Nonmammalian/metabolism
- Embryo, Nonmammalian/physiology
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- Gene Expression Regulation, Developmental
- Phenotype
- Animals, Genetically Modified
- Animals
- Time Factors
- Retinal Vessels/embryology
- Retinal Vessels/physiology
- Cell Proliferation
- Stem Cell Niche
- Cell Lineage*
- Zebrafish/embryology
- Zebrafish/genetics
- Zebrafish/metabolism
- Zebrafish/physiology*
- Embryonic Stem Cells/metabolism
- Embryonic Stem Cells/physiology*
- Retina/embryology
- Retina/metabolism
- Retina/physiology*
- Cell Differentiation*
- PubMed
- 28465291 Full text @ J. Cell Biol.
Citation
Tang, X., Gao, J., Jia, X., Zhao, W., Zhang, Y., Pan, W., He, J. (2017) Bipotent progenitors as embryonic origin of retinal stem cells. The Journal of cell biology. 216(6):1833.
Abstract
In lower vertebrates, retinal stem cells (RSCs) capable of producing all retinal cell types are a resource for retinal tissue growth throughout life. However, the embryonic origin of RSCs remains largely elusive. Using a Zebrabow-based clonal analysis, we characterized the RSC niche in the ciliary marginal zone of zebrafish retina and illustrate that blood vessels associated with RSCs are required for the maintenance of actively proliferating RSCs. Full lineage analysis of RSC progenitors reveals lineage patterns of RSC production. Moreover, in vivo lineage analysis demonstrates that these RSC progenitors are the direct descendants of a set of bipotent progenitors in the medial epithelial layer of developing optic vesicles, suggesting the involvement of the mixed-lineage states in the RSC lineage specification.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping