ZFIN ID: ZDB-PUB-170430-2
Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches
Gioacchini, G., Rossi, G., Carnevali, O.
Date: 2017
Source: Scientific Reports 7: 1261 (Journal)
Registered Authors: Carnevali, Oliana
Keywords: Immunology, Microbiology, Molecular biology
MeSH Terms:
  • Administration, Oral
  • Animals
  • Endocannabinoids/metabolism*
  • Immunologic Factors/administration & dosage*
  • Intestinal Mucosa/immunology*
  • Probiotics/administration & dosage*
  • Zebrafish
PubMed: 28455493 Full text @ Sci. Rep.
The endocannabinoid system plays an important role in regulating inflammation in several chronic or anomalous gut inflammatory diseases. In vivo and ex vivo studies showed that 30 days treatment with a probiotic mix activated the endocannabinoid system in zebrafish. These results highlight the potential of this probiotic mixture to regulate immune cell function, by inducing gene expression of toll-like receptors and other immune related molecules. Furthermore, TUNEL assay showed a decrease in the number of apoptotic cells, and this finding was supported by a reduction in pro-apoptotic factors and an increase in anti-apoptotic molecules. The results presented here strengthen the molecular mechanisms activated by probiotic mix controlling immune response and inflammation.