PUBLICATION
Evolution of the Groucho/Tle gene family: gene organization and duplication events.
- Authors
- Bajoghli, B.
- ID
- ZDB-PUB-170320-1
- Date
- 2007
- Source
- Development genes and evolution 217(8): 613-618 (Journal)
- Registered Authors
- Bajoghli, Baubak
- Keywords
- Groucho, Tle, Ciona, Gene duplication, Evolution
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Basic Helix-Loop-Helix Transcription Factors/genetics*
- Chordata/genetics
- Drosophila Proteins/genetics*
- Evolution, Molecular*
- Gene Duplication*
- Genetic Variation
- Molecular Sequence Data
- Multigene Family*
- Phylogeny
- Repressor Proteins/genetics*
- Sequence Homology, Amino Acid
- PubMed
- 17624551 Full text @ Dev. Genes Evol.
Citation
Bajoghli, B. (2007) Evolution of the Groucho/Tle gene family: gene organization and duplication events.. Development genes and evolution. 217(8):613-618.
Abstract
The Groucho/Tle family of corepressor proteins has important roles in development and in adult tissue in both Protostomes and Deuterostomes. In Drosophila, a single member of this family has been identified. Unlike in Protostomes, most Deutrostomes contain more than two full-length Tle genes. In this study, I analyse the genomic organization and phylogenetic relationship between the long and short forms of the Groucho/Tle family members in Chordata. The genomic location and sequence similarities suggest that Aes/Grg5 and Tle6/Grg6 arose from duplication of the Tle2 gene; each evolved independently and acquired new functions as negative regulators of the other Tle proteins. Based on these data, a model for Groucho/Tle gene evolution is proposed.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping