PUBLICATION

Zebrafish - An emerging model system to explore thyroid hormone transporters

Authors
Zada, D., Blitz, E., Appelbaum, L.
ID
ZDB-PUB-170310-7
Date
2017
Source
Molecular and Cellular Endocrinology   459: 53-58 (Review)
Registered Authors
Appelbaum, Lior, Blitz, Einat, Zada, David
Keywords
MCT8, Mental retardation, OATP1C1, Thyroid, Thyroid transporters, Zebrafish
MeSH Terms
  • Organic Anion Transporters/genetics*
  • Organic Anion Transporters/metabolism
  • Thyroid Hormones/genetics*
  • Thyroid Hormones/metabolism
  • Protein Isoforms/deficiency
  • Protein Isoforms/genetics
  • Carrier Proteins/genetics*
  • Carrier Proteins/metabolism
  • Gene Knockout Techniques
  • Protein Binding
  • Signal Transduction
  • Disease Models, Animal
  • Monocarboxylic Acid Transporters/deficiency
  • Monocarboxylic Acid Transporters/genetics*
  • Animals
  • Protein Transport
  • Larva/genetics
  • Larva/growth & development
  • Larva/metabolism
  • Humans
  • Gene Expression Regulation, Developmental
  • X-Linked Intellectual Disability/genetics*
  • X-Linked Intellectual Disability/metabolism
  • X-Linked Intellectual Disability/pathology
  • Brain/metabolism
  • Brain/pathology
  • Muscle Hypotonia/genetics*
  • Muscle Hypotonia/metabolism
  • Muscle Hypotonia/pathology
  • Zebrafish/genetics*
  • Zebrafish/growth & development
  • Zebrafish/metabolism
  • Muscular Atrophy/genetics*
  • Muscular Atrophy/metabolism
  • Muscular Atrophy/pathology
PubMed
28274736 Full text @ Mol. Cell. Endocrinol.
Abstract
Thyroid hormones (THs) regulate a variety of fundamental physiological processes, including the development and maintenance of the brain. For decades, it was thought that THs enter the cells by passive diffusion. However, it is now clear that TH transport across the cell membrane requires specific transporter proteins that facilitate the uptake and efflux of THs. Several thyroid hormone transmembrane transporters (THTTs) have been identified, including monocarboxylate transporter 8 (MCT8), MCT10, and organic anion transporting polypeptide 1C1 (OATP1C1). The critical role of THTTs in regulating metabolism and brain function is demonstrated in the Allan-Herndon-Dudley syndrome (AHDS), an X-linked psychomotor retardation associated with mutations in the MCT8/SLC16A2 gene. In addition to traditional research on humans, cell-lines, and rodents, the zebrafish has recently emerged as an attractive model to study THTTs and neuroendocrinological-related disorders. In this review, we describe the unique contribution of zebrafish studies to the understanding of the functional role of THTTs in live animals, and how this transparent vertebrate model can be used for translational studies on TH-related disorders.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping