ZFIN ID: ZDB-PUB-170310-7
Zebrafish - An emerging model system to explore thyroid hormone transporters
Zada, D., Blitz, E., Appelbaum, L.
Date: 2017
Source: Molecular and Cellular Endocrinology   459: 53-58 (Review)
Registered Authors: Appelbaum, Lior, Blitz, Einat, Zada, David
Keywords: MCT8, Mental retardation, OATP1C1, Thyroid, Thyroid transporters, Zebrafish
MeSH Terms:
  • Animals
  • Brain/metabolism
  • Brain/pathology
  • Carrier Proteins/genetics*
  • Carrier Proteins/metabolism
  • Disease Models, Animal
  • Gene Expression Regulation, Developmental
  • Gene Knockout Techniques
  • Humans
  • Larva/genetics
  • Larva/growth & development
  • Larva/metabolism
  • Mental Retardation, X-Linked/genetics*
  • Mental Retardation, X-Linked/metabolism
  • Mental Retardation, X-Linked/pathology
  • Monocarboxylic Acid Transporters/deficiency
  • Monocarboxylic Acid Transporters/genetics*
  • Muscle Hypotonia/genetics*
  • Muscle Hypotonia/metabolism
  • Muscle Hypotonia/pathology
  • Muscular Atrophy/genetics*
  • Muscular Atrophy/metabolism
  • Muscular Atrophy/pathology
  • Organic Anion Transporters/genetics*
  • Organic Anion Transporters/metabolism
  • Protein Binding
  • Protein Isoforms/deficiency
  • Protein Isoforms/genetics
  • Protein Transport
  • Signal Transduction
  • Thyroid Hormones/genetics*
  • Thyroid Hormones/metabolism
  • Zebrafish/genetics*
  • Zebrafish/growth & development
  • Zebrafish/metabolism
PubMed: 28274736 Full text @ Mol. Cell. Endocrinol.
Thyroid hormones (THs) regulate a variety of fundamental physiological processes, including the development and maintenance of the brain. For decades, it was thought that THs enter the cells by passive diffusion. However, it is now clear that TH transport across the cell membrane requires specific transporter proteins that facilitate the uptake and efflux of THs. Several thyroid hormone transmembrane transporters (THTTs) have been identified, including monocarboxylate transporter 8 (MCT8), MCT10, and organic anion transporting polypeptide 1C1 (OATP1C1). The critical role of THTTs in regulating metabolism and brain function is demonstrated in the Allan-Herndon-Dudley syndrome (AHDS), an X-linked psychomotor retardation associated with mutations in the MCT8/SLC16A2 gene. In addition to traditional research on humans, cell-lines, and rodents, the zebrafish has recently emerged as an attractive model to study THTTs and neuroendocrinological-related disorders. In this review, we describe the unique contribution of zebrafish studies to the understanding of the functional role of THTTs in live animals, and how this transparent vertebrate model can be used for translational studies on TH-related disorders.