PUBLICATION
Zebrafish - An emerging model system to explore thyroid hormone transporters
- Authors
- Zada, D., Blitz, E., Appelbaum, L.
- ID
- ZDB-PUB-170310-7
- Date
- 2017
- Source
- Molecular and Cellular Endocrinology 459: 53-58 (Review)
- Registered Authors
- Appelbaum, Lior, Blitz, Einat, Zada, David
- Keywords
- MCT8, Mental retardation, OATP1C1, Thyroid, Thyroid transporters, Zebrafish
- MeSH Terms
-
- Gene Expression Regulation, Developmental
- Monocarboxylic Acid Transporters/deficiency
- Monocarboxylic Acid Transporters/genetics*
- Protein Transport
- Gene Knockout Techniques
- Signal Transduction
- Humans
- Larva/genetics
- Larva/growth & development
- Larva/metabolism
- Muscle Hypotonia/genetics*
- Muscle Hypotonia/metabolism
- Muscle Hypotonia/pathology
- X-Linked Intellectual Disability/genetics*
- X-Linked Intellectual Disability/metabolism
- X-Linked Intellectual Disability/pathology
- Carrier Proteins/genetics*
- Carrier Proteins/metabolism
- Thyroid Hormones/genetics*
- Thyroid Hormones/metabolism
- Animals
- Protein Binding
- Disease Models, Animal
- Brain/metabolism
- Brain/pathology
- Protein Isoforms/deficiency
- Protein Isoforms/genetics
- Organic Anion Transporters/genetics*
- Organic Anion Transporters/metabolism
- Muscular Atrophy/genetics*
- Muscular Atrophy/metabolism
- Muscular Atrophy/pathology
- Zebrafish/genetics*
- Zebrafish/growth & development
- Zebrafish/metabolism
- PubMed
- 28274736 Full text @ Mol. Cell. Endocrinol.
Citation
Zada, D., Blitz, E., Appelbaum, L. (2017) Zebrafish - An emerging model system to explore thyroid hormone transporters. Molecular and Cellular Endocrinology. 459:53-58.
Abstract
Thyroid hormones (THs) regulate a variety of fundamental physiological processes, including the development and maintenance of the brain. For decades, it was thought that THs enter the cells by passive diffusion. However, it is now clear that TH transport across the cell membrane requires specific transporter proteins that facilitate the uptake and efflux of THs. Several thyroid hormone transmembrane transporters (THTTs) have been identified, including monocarboxylate transporter 8 (MCT8), MCT10, and organic anion transporting polypeptide 1C1 (OATP1C1). The critical role of THTTs in regulating metabolism and brain function is demonstrated in the Allan-Herndon-Dudley syndrome (AHDS), an X-linked psychomotor retardation associated with mutations in the MCT8/SLC16A2 gene. In addition to traditional research on humans, cell-lines, and rodents, the zebrafish has recently emerged as an attractive model to study THTTs and neuroendocrinological-related disorders. In this review, we describe the unique contribution of zebrafish studies to the understanding of the functional role of THTTs in live animals, and how this transparent vertebrate model can be used for translational studies on TH-related disorders.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping