PUBLICATION
Hepatotoxicity of benzotriazole and its effect on the cadmium induced toxicity in zebrafish Danio rerio
- Authors
- Duan, Z., Xing, Y., Feng, Z., Zhang, H., Li, C., Gong, Z., Wang, L., Sun, H.
- ID
- ZDB-PUB-170306-2
- Date
- 2017
- Source
- Environmental pollution (Barking, Essex : 1987) 224: 706-713 (Journal)
- Registered Authors
- Keywords
- Benzotriazole, Cadmium, Complexation, Hepatotoxicity, Zebrafish
- MeSH Terms
-
- Animals
- Cadmium/metabolism
- Cadmium/toxicity*
- Inactivation, Metabolic
- Liver/drug effects*
- Metals, Heavy/metabolism
- Superoxide Dismutase/metabolism
- Triazoles/toxicity*
- Zebrafish*/metabolism
- PubMed
- 28259580 Full text @ Environ. Pollut.
Citation
Duan, Z., Xing, Y., Feng, Z., Zhang, H., Li, C., Gong, Z., Wang, L., Sun, H. (2017) Hepatotoxicity of benzotriazole and its effect on the cadmium induced toxicity in zebrafish Danio rerio. Environmental pollution (Barking, Essex : 1987). 224:706-713.
Abstract
As an emerging contaminant, 1-H-benzotriazole (1H-BTR) has been detected in the engineered and natural aquatic environments, which usually coexists with heavy metals and causes combined pollution. In the present study, wild-type and transgenic zebrafish Danio rerio were used to explore the acute toxicity as well as the single and joint hepatotoxicity of cadmium (Cd) and 1H-BTR. Although the acute toxicity of 1H-BTR to zebrafish was low, increased expression of liver-specific fatty acid binding protein was observed in transgenic zebrafish when the embryos were exposed to 5.0 μM of 1H-BTR for 30 days. Besides, co-exposure to 1H-BTR not only reduced the acute toxic effects induced by Cd, but also alleviated the Cd-induced liver atrophy in transgenic fish. Correspondingly, effects of combined exposure to 1H-BTR on the Cd-induced expressions of several signal pathway-related genes and superoxide dismutase and glutathione-s-transferase proteins were studied. Based on the determination of Cd bioaccumulation in fish and the complexing stability constant (β) of Cd-BTR complex in solution, the detoxification mechanism of co-existing 1H-BTR on Cd to the zebrafish was discussed.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping