PUBLICATION
Computational approaches for understanding the diagnosis and treatment of Parkinson's disease
- Authors
- Smith, S.L., Lones, M.A., Bedder, M., Alty, J.E., Cosgrove, J., Maguire, R.J., Pownall, M.E., Ivanoiu, D., Lyle, C., Cording, A., Elliott, C.J.
- ID
- ZDB-PUB-170214-79
- Date
- 2015
- Source
- IET systems biology 9: 226-33 (Review)
- Registered Authors
- Cording, Amy
- Keywords
- none
- MeSH Terms
-
- Algorithms*
- Animals
- Antiparkinson Agents/therapeutic use*
- Diagnosis, Computer-Assisted/methods*
- Drosophila melanogaster
- Female
- Humans
- Male
- Parkinson Disease/diagnosis*
- Parkinson Disease/drug therapy*
- Zebrafish
- PubMed
- 26577157 Full text @ IET Syst Biol
Citation
Smith, S.L., Lones, M.A., Bedder, M., Alty, J.E., Cosgrove, J., Maguire, R.J., Pownall, M.E., Ivanoiu, D., Lyle, C., Cording, A., Elliott, C.J. (2015) Computational approaches for understanding the diagnosis and treatment of Parkinson's disease. IET systems biology. 9:226-33.
Abstract
This study describes how the application of evolutionary algorithms (EAs) can be used to study motor function in humans with Parkinson's disease (PD) and in animal models of PD. Human data is obtained using commercially available sensors via a range of non-invasive procedures that follow conventional clinical practice. EAs can then be used to classify human data for a range of uses, including diagnosis and disease monitoring. New results are presented that demonstrate how EAs can also be used to classify fruit flies with and without genetic mutations that cause Parkinson's by using measurements of the proboscis extension reflex. The case is made for a computational approach that can be applied across human and animal studies of PD and lays the way for evaluation of existing and new drug therapies in a truly objective way.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping