PUBLICATION
Zygotic genome activation during the maternal-to-zygotic transition
- Authors
- Lee, M.T., Bonneau, A.R., Giraldez, A.J.
- ID
- ZDB-PUB-170214-299
- Date
- 2014
- Source
- Annual Review of Cell and Developmental Biology 30: 581-613 (Review)
- Registered Authors
- Giraldez, Antonio, Lee, Miler
- Keywords
- cellular reprogramming, embryogenesis, maternal clearance, pioneer factors, pluripotency
- MeSH Terms
-
- Animals
- Cell Cycle
- Chromatin/genetics
- Chromatin/ultrastructure
- Drosophila Proteins/physiology
- Egg Proteins/genetics
- Embryo, Nonmammalian
- Embryonic Development/genetics*
- Female
- Gene Expression Regulation, Developmental*/drug effects
- High-Throughput Nucleotide Sequencing
- Histones/physiology
- Humans
- Models, Genetic
- Oocytes/metabolism
- Pregnancy
- RNA Stability
- RNA, Messenger/biosynthesis
- RNA, Messenger/genetics
- RNA, Messenger, Stored/genetics*
- Transcription Factors/genetics
- Transcription, Genetic*/drug effects
- Transcriptome
- Xenopus Proteins/physiology
- Zebrafish Proteins/physiology
- Zygote/metabolism*
- PubMed
- 25150012 Full text @ Annu. Rev. Cell Dev. Biol.
Citation
Lee, M.T., Bonneau, A.R., Giraldez, A.J. (2014) Zygotic genome activation during the maternal-to-zygotic transition. Annual Review of Cell and Developmental Biology. 30:581-613.
Abstract
Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In animals, maternal factors contributed by the egg cytoplasm initially control development, whereas the zygotic nuclear genome is quiescent. Subsequently, the genome is activated, embryonic gene products are mobilized, and maternal factors are cleared. This transfer of developmental control is called the maternal-to-zygotic transition (MZT). In this review, we discuss recent advances toward understanding the scope, timing, and mechanisms that underlie zygotic genome activation at the MZT in animals. We describe high-throughput techniques to measure the embryonic transcriptome and explore how regulation of the cell cycle, chromatin, and transcription factors together elicits specific patterns of embryonic gene expression. Finally, we illustrate the interplay between zygotic transcription and maternal clearance and show how these two activities combine to reprogram two terminally differentiated gametes into a totipotent embryo.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping