PUBLICATION
Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-κB and ERK/MAPK Signaling Pathways
- Authors
- Liu, Y., Zhu, P., Wang, Y., Wei, Z., Tao, L., Zhu, Z., Sheng, X., Wang, S., Ruan, J., Liu, Z., Cao, Y., Shan, Y., Sun, L., Wang, A., Chen, W., Lu, Y.
- ID
- ZDB-PUB-170214-190
- Date
- 2015
- Source
- PLoS One 10: e0123781 (Journal)
- Registered Authors
- Keywords
- Transcription factors, Breast cancer, Metastasis, Cancer treatment, Cancer cell migration, MAPK signaling cascades, Garlic, Zebrafish
- MeSH Terms
-
- Allyl Compounds/chemistry
- Allyl Compounds/pharmacology*
- Animals
- Breast Neoplasms/drug therapy*
- Breast Neoplasms/metabolism
- Breast Neoplasms/pathology
- Cell Line, Tumor
- Cell Movement/drug effects
- Drug Screening Assays, Antitumor
- Female
- Humans
- MAP Kinase Signaling System/drug effects*
- Matrix Metalloproteinase 2/biosynthesis*
- Matrix Metalloproteinase 9/biosynthesis*
- NF-kappa B/metabolism*
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Neoplasm Proteins/metabolism*
- Sulfides/chemistry
- Sulfides/pharmacology*
- Zebrafish
- PubMed
- 25927362 Full text @ PLoS One
Citation
Liu, Y., Zhu, P., Wang, Y., Wei, Z., Tao, L., Zhu, Z., Sheng, X., Wang, S., Ruan, J., Liu, Z., Cao, Y., Shan, Y., Sun, L., Wang, A., Chen, W., Lu, Y. (2015) Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-κB and ERK/MAPK Signaling Pathways. PLoS One. 10:e0123781.
Abstract
Background Migration and invasion are two crucial steps of tumor metastasis. Blockage of these steps may be an effective strategy to reduce the risk. The objective of the present study was to investigate the effects of diallyl trisulfide (DATS), a natural organosulfuric compound with most sulfur atoms found in garlic, on migration and invasion in triple negative breast cancer (TNBC) cells. Molecular mechanisms underlying the anticancer effects of DATS were further investigated.
Methods and results MDA-MB-231 cells and HS 578t breast cancer cells were treated with different concentrations of DATS. DATS obviously suppressed the migration and invasion of two cell lines and changed the morphological. Moreover, DATS inhibited the mRNA/protein/ enzymes activities of MMP2/9 via attenuating the NF-κB pathway. DATS also inhibited ERK/MAPK rather than p38 and JNK.
Conclusion DATS inhibits MMP2/9 activity and the metastasis of TNBC cells, and emerges as a potential anti-cancer agent. The inhibitory effects are associated with down-regulation of the transcriptional activities of NF-κB and ERK/MAPK signaling pathways.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping